MK-0812 (Succinate)

Product Name: MK-0812 (Succinate)
CAS No.: 851916-42-2
Chemical Name: MK-0812 (Succinate)
Synonyms: MK-0812 HCL;MK-0812 (Succinate);MK-0812 Succinate, 10 mM in DMSO;MK 0812 SUCCINATE;MK0812 SUCCINATE;CC chemokine receptor,MK 0812,Inhibitor,MK0812 Succinate,CCR,MK 0812 Succinate,MK0812,MK-0812,inhibit
CBNumber: CB13146616
Molecular Formula: C28H40F3N3O7
Formula Weight: 587.64
MOL File: 851916-42-2.mol

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MK-0812 (Succinate) Property

storage temp.: Store at -20°C
solubility: DMSO: ≥ 32 mg/mL (54.46 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5928
Product name: MK-0812Succinate
Purity: 99.69%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5928
Product name: MK-0812Succinate
Purity: 99.69%
Packaging: 10mg
Price: $336
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611767
Product name: MK-0812 succinate
Packaging: 10mg
Price: $460.7
Updated: 2021/12/16

ChemScene

Product number: CS-5928
Product name: MK-0812Succinate
Purity: 99.69%
Packaging: 50mg
Price: $1176
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611767
Product name: MK-0812 succinate
Packaging: 50mg
Price: $1184.9
Updated: 2021/12/16

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MK-0812 (Succinate) Chemical Properties,Usage,Production

Description

MK0812 Succinate is a dual CCR2-CCR5 receptor antagonist.

Uses

MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.

in vivo

MK-0812 (30 mg/kg, p.o.) reduces the frequency of Ly6G^-Ly6C^hi monocytes in the peripheral blood, while no impact on circulating Ly6G⁺Ly6C⁺ neutrophil frequency is observed. In addition, MK-0812 treatment causes a dose-dependent reduction in circulating Ly6C^hi monocytes and a corresponding elevation in the CCR2 ligand CCL2^[1]. MK-0812 is administered by continuous i.v. infusion to maintain a constant level of the drug in blood^[2].

IC 50

CCR2

References

[1] Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6. DOI:10.1016/j.bbrc.2009.12.025
[2] Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.J Immunol Methods. 2010 Jan 31;352(1-2):101-10. DOI:10.1016/j.jim.2009.10.010

MK-0812 (Succinate) Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-0812 (Succinate) Suppliers

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851916-42-2, MK-0812 (Succinate)Related Search:

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide MK-8998 MK-4101 MK8745 MK-3903 mk-1064 MK 0557 MKC9989 MKC3946

MK-0812 (Succinate)

MK-0812 HCL

MK 0812 SUCCINATE;MK0812 SUCCINATE

CC chemokine receptor,MK 0812,Inhibitor,MK0812 Succinate,CCR,MK 0812 Succinate,MK0812,MK-0812,inhibit

MK-0812 Succinate, 10 mM in DMSO

851916-42-2

C28H40F3N3O7