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MK-0812 (Succinate)

Product Name
MK-0812 (Succinate)
CAS No.
851916-42-2
Chemical Name
MK-0812 (Succinate)
Synonyms
MK-0812 HCL;MK-0812 (Succinate);MK-0812 Succinate, 10 mM in DMSO;MK 0812 SUCCINATE;MK0812 SUCCINATE;CC chemokine receptor,MK 0812,Inhibitor,MK0812 Succinate,CCR,MK 0812 Succinate,MK0812,MK-0812,inhibit
CBNumber
CB13146616
Molecular Formula
C28H40F3N3O7
Formula Weight
587.64
MOL File
851916-42-2.mol
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MK-0812 (Succinate) Property

storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 32 mg/mL (54.46 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5928
Product name
MK-0812Succinate
Purity
99.69%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-5928
Product name
MK-0812Succinate
Purity
99.69%
Packaging
10mg
Price
$336
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611767
Product name
MK-0812 succinate
Packaging
10mg
Price
$460.7
Updated
2021/12/16
ChemScene
Product number
CS-5928
Product name
MK-0812Succinate
Purity
99.69%
Packaging
50mg
Price
$1176
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611767
Product name
MK-0812 succinate
Packaging
50mg
Price
$1184.9
Updated
2021/12/16
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MK-0812 (Succinate) Chemical Properties,Usage,Production

Description

MK0812 Succinate is a dual CCR2-CCR5 receptor antagonist.

Uses

MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.

in vivo

MK-0812 (30 mg/kg, p.o.) reduces the frequency of Ly6G-Ly6Chi monocytes in the peripheral blood, while no impact on circulating Ly6G+Ly6C+ neutrophil frequency is observed. In addition, MK-0812 treatment causes a dose-dependent reduction in circulating Ly6Chi monocytes and a corresponding elevation in the CCR2 ligand CCL2[1]. MK-0812 is administered by continuous i.v. infusion to maintain a constant level of the drug in blood[2].

IC 50

CCR2

References

[1] Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6. DOI:10.1016/j.bbrc.2009.12.025
[2] Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.J Immunol Methods. 2010 Jan 31;352(1-2):101-10. DOI:10.1016/j.jim.2009.10.010

MK-0812 (Succinate) Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-0812 (Succinate) Suppliers

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851916-42-2, MK-0812 (Succinate)Related Search:

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  • MK-0812 (Succinate)
  • MK-0812 HCL
  • MK 0812 SUCCINATE;MK0812 SUCCINATE
  • CC chemokine receptor,MK 0812,Inhibitor,MK0812 Succinate,CCR,MK 0812 Succinate,MK0812,MK-0812,inhibit
  • MK-0812 Succinate, 10 mM in DMSO
  • 851916-42-2
  • C28H40F3N3O7