1-Ethyl-2,3-dioxopiperazine
- Product Name
- 1-Ethyl-2,3-dioxopiperazine
- CAS No.
- 59702-31-7
- Chemical Name
- 1-Ethyl-2,3-dioxopiperazine
- Synonyms
- 1-ETHYLPIPERAZINE-2,3-DIONE;4-ETHYL-2,3-DIOXYPIPERAZINE;T 1982C;3-dioxopiperazine;-2,3-dioxopiperazine;Piperacillin IMpurity E;Piperacillin EP Impurity;Piperacillin EP Impurity E;1-ethylpiperazine-2,3-diol;N-ETHYLPIPERAZINE-2,3-DIONE
- CBNumber
- CB4479987
- Molecular Formula
- C6H10N2O2
- Formula Weight
- 142.16
- MOL File
- 59702-31-7.mol
1-Ethyl-2,3-dioxopiperazine Property
- Melting point:
- 106-110 °C(lit.)
- Boiling point:
- 259.72°C (rough estimate)
- Density
- 0.64
- refractive index
- 1.5010 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 2000 g/L
- form
- Solid
- pka
- 12.57±0.20(Predicted)
- color
- White to Off-White
- Water Solubility
- 2000 g/L
- BRN
- 879076
- InChI
- InChI=1S/C6H10N2O2/c1-2-8-4-3-7-5(9)6(8)10/h2-4H2,1H3,(H,7,9)
- InChIKey
- ZBEKOEYCWKIMGU-UHFFFAOYSA-N
- SMILES
- N1(CC)CCNC(=O)C1=O
- CAS DataBase Reference
- 59702-31-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR3085
- Product name
- Piperacillin Related Compound E
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 50MG
- Price
- $433
- Updated
- 2025/07/31
- Product number
- 1541529
- Product name
- Piperacillin Related Compound E
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $1200
- Updated
- 2025/07/31
- Product number
- PH011088
- Product name
- 1-ethyl-2,3-piperazinedione
- Purity
- AldrichCPR
- Packaging
- 500mg
- Price
- $172
- Updated
- 2023/06/20
- Product number
- E0459
- Product name
- 1-Ethyl-2,3-dioxopiperazine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $140
- Updated
- 2025/07/31
- Product number
- E0459
- Product name
- 1-Ethyl-2,3-dioxopiperazine
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $1045
- Updated
- 2025/07/31
1-Ethyl-2,3-dioxopiperazine Chemical Properties,Usage,Production
Chemical Properties
1-Ethyl-2,3-dioxopiperazine is WHITE TO PALE YELLOW CRYSTALLINE POWDER
Uses
1-Ethyl-2,3-dioxopiperazine (Piperacillin EP Impurity E; Piperacillin USP Related Compound E) is an intermediate used in the new process for the synthesis of Piperacillin sodium.
Uses
1-Ethyl-2,3-dioxopiperazine is an intermediate used in the new process for the synthesis of Piperacillin sodium.
Synthesis
110-72-5
95-92-1
59702-31-7
A. Prepare Mixed Solution A by dissolving 11 g of N-ethyl ethylenediamine in 8 g of anhydrous methanol.B. Add 25 ml of anhydrous methanol to a dry three-necked flask and 2 g of glacial acetic acid under stirring, and when it is completely dissolved, 11 g of diethyl oxalate was slowly added at 25-30 °C, and the temperature of the reaction system was subsequently lowered to 15-20 °C. This mixed solution was transferred to a dropping funnel and set aside.C. Mixed Solution A was slowly added dropwise to Mixed Solution B, keeping the reaction temperature between 30-50 °C for 30-50 min. After the reaction was completed, the temperature was raised to 50°C and the reaction was continued for 1 hour. At the end of the reaction, methanol was removed by concentration under reduced pressure.D. 66 ml of solvent B was added to the reaction mixture and the temperature of the system was slowly lowered from 50 °C to room temperature (25-30 °C) to allow the product to crystallize slowly. Finally 14.77 g of N-ethyl-2,3-dioxopiperazine was obtained in 83.21% yield and 99.32% purity.
References
[1] Patent: CN107417630, 2017, A. Location in patent: Paragraph 0017-0041
1-Ethyl-2,3-dioxopiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Ethyl-2,3-dioxopiperazine Suppliers
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- Fax
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- info@trc-canada.com
- Country
- Canada
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- 6038
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View Lastest Price from 1-Ethyl-2,3-dioxopiperazine manufacturers
- Product
- 1-Ethyl-2,3-dioxopiperazine 59702-31-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
- Product
- 1-Ethyl-2,3-dioxopiperazine 59702-31-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06
- Product
- N-Ethyl-2,3-dioxopiperazine 59702-31-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%
- Supply Ability
- 20 tons
- Release date
- 2023-07-12