ChemicalBook > CAS DataBase List > AZ304

AZ304

Product Name
AZ304
CAS No.
942507-42-8
Chemical Name
AZ304
Synonyms
AZ304;AZ304;AZ-304;AZ 304;inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf;3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide;3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-
CBNumber
CB44808617
Molecular Formula
C27H25N5O2
Formula Weight
451.52
MOL File
942507-42-8.mol
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AZ304 Property

Boiling point:
582.6±50.0 °C(Predicted)
Density 
1.270±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
12.87±0.70(Predicted)
color 
White to off-white
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0064828
Product name
AZ304
Purity
99.39%
Packaging
25mg
Price
$150
Updated
2021/12/16
Apolloscientific
Product number
BISN0220
Product name
3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
Packaging
5mg
Price
$160
Updated
2021/12/16
ChemScene
Product number
CS-0064828
Product name
AZ304
Purity
99.39%
Packaging
50mg
Price
$250
Updated
2021/12/16
Apolloscientific
Product number
BISN0220
Product name
3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
Packaging
10mg
Price
$261
Updated
2021/12/16
ChemScene
Product number
CS-0064828
Product name
AZ304
Purity
99.39%
Packaging
100mg
Price
$450
Updated
2021/12/16
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AZ304 Chemical Properties,Usage,Production

Uses

AZ304 is potent dual BRAF inhibitor. Is a combination of MEK and B-raf inhibitors for treatment of cancer.

Biological Activity

AZ304 is a synthetic inhibitor targeting wild-type and V600E mutant BRAF with IC50 of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R with IC50 below 100 nM.

in vitro

AZ304 inhibited wild-type BRAF and CRAF, BRAF in vitro.

in vivo

In both RKO and Caco-2 tumor models, administration of AZ304 alone or in combination with Cetuximab resulted in antitumor activity without apparent toxic effects (regardless of BRAF mutation).

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> BRAF(V600E)
(Cell-free assay) < /tr>
TargetValue
p38
(Cell-free assay)		 6 nM
CSF1R
(Cell-free assay)		 35 nM
38 nM
CRAF
(Cell-free assay )		 68 nM
WT BRAF
(Cell-free assay)		 79 nM

AZ304 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ304 Suppliers

China 41 India 1 United States 4 USA 1 Global 47
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

942507-42-8, AZ304Related Search:


  • AZ304;AZ-304;AZ 304
  • AZ304
  • Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-
  • 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
  • 3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide
  • inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf
  • 942507-42-8
  • API