1-Chloro-N,N,2-trimethylpropenylamine
- Product Name
- 1-Chloro-N,N,2-trimethylpropenylamine
- CAS No.
- 26189-59-3
- Chemical Name
- 1-Chloro-N,N,2-trimethylpropenylamine
- Synonyms
- 1-Chloro-N,N,2-trimethylprop-1-en-1-amine;1-CHLORO-N,N,2-TRIMETHYL-1-PROPENYLAMINE;Ghosez′s reagent;TETRAMETHYL-ALPHA-CHLORENAMINE;1-CHLORO-N,N,2-TRIMETHYLPROPENYLAMINE;(1-CHLORO-2-METHYLPROPENYL)DIMETHYLAMINE;1-chloro-N,N,2-trimethyl-1-Propen-1-amine;1-chloride-N, N, 2-trimethyl-1-acrylamine;1-Chloro-N,N,2-trimethylpropenylamine ,98%;1-Propen-1-amine, 1-chloro-N,N,2-trimethyl-
- CBNumber
- CB4484804
- Molecular Formula
- C6H12ClN
- Formula Weight
- 133.62
- MOL File
- 26189-59-3.mol
1-Chloro-N,N,2-trimethylpropenylamine Property
- Boiling point:
- 129-130 °C(lit.)
- Density
- 1.01 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.453(lit.)
- Flash point:
- 80 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Liquid
- pka
- 4.27±0.70(Predicted)
- color
- Colorless to yellow
- Stability:
- Hygroscopic, Moisture Sensitive, Unstable in Solution
Safety
- Hazard Codes
- C
- Risk Statements
- 10-34
- Safety Statements
- 16-26-36/37/39-45
- RIDADR
- UN 2734 8/PG 1
- WGK Germany
- 3
- HS Code
- 29211990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 498270
- Product name
- 1-Chloro-N,N,2-trimethyl-1-propenylamine
- Purity
- 96%
- Packaging
- 5ml
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 498270
- Product name
- 1-Chloro-N,N,2-trimethyl-1-propenylamine
- Purity
- 96%
- Packaging
- 50ml
- Price
- $1270
- Updated
- 2024/03/01
- Product number
- 498270
- Product name
- 1-Chloro-N,N,2-trimethyl-1-propenylamine
- Purity
- 96%
- Packaging
- 250ml
- Price
- $6300
- Updated
- 2024/03/01
- Product number
- C349260
- Product name
- 1-Chloro-N,N-2-trimethylpropenylamine
- Packaging
- 2.5g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- C349260
- Product name
- 1-Chloro-N,N-2-trimethylpropenylamine
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
1-Chloro-N,N,2-trimethylpropenylamine Chemical Properties,Usage,Production
Chemical Properties
Colorless to yellow liquid
Uses
1-Chloro-N,N,2-trimethyl-1-propenylamine is an acid halogenation reagent developed by Ghosez, that enables the conversion of carboxylic acids into the corresponding chlorides under strictly neutral conditions. This method was successfully used in the total synthesis of caloporoside, roseophilin, (-)-enniatin B, (±)-epimeloscine and (±)-meloscine.
Preparation
1-chloro-N,N,2-trimethylpropenylamine is conveniently prepared by the reaction of N,N,2-
trimethylpropanamide with Phosgene followed by dehydrochlorination of the intermediate α-chloroiminium
chloride (eq 1).[1,2] Recent unpublished results of our laboratory have shown that Phosphorus Oxychloride or dior triphosgene can also be used for the preparation of TMCE.
Application
1-Chloro-N,N,2-trimethylpropenylamine (TMCE) is used to mild halogenation of alcohols and acids under neutral conditions; conversion of N-protected amino acids into peptides without racemization; coupling of acids and allylic alcohols with organometallics; [2 + 2] cycloaddition synthons, more reactive than dimethylketene.
Synthesis Reference(s)
Journal of the American Chemical Society, 94, p. 2869, 1972 DOI: 10.1021/ja00763a061
Organic Syntheses, Coll. Vol. 6, p. 282, 1988
Tetrahedron Letters, 25, p. 5043, 1984 DOI: 10.1016/S0040-4039(01)91114-1
storage
1-chloro-N,N,2-propenylamines are thermally stable. It must be transferred in the absence of moisture and stored under nitrogen in sealed tubes. In spite of these precautions, light precipitates sometimes may form. 1-Iodo-N,N,2-trimethylpropenylamine is less stable and should be used when freshly prepared.
References
1. Ghosez, L.; Marchand-Brynaert, J. In Advances in Organic Chemistry; Raphael, R. A.; Taylor, E. C.; Wynberg, H.,
Eds.; Interscience: New York, 1976; Part 1, pp 421-523.
2. (a) Haveaux, B.; Dekoker, A.; Rens, M.; Sidani, A. R.; Toye, J.; Ghosez, L. OS 1979, 59, 26. (b) Ghosez, L.; Koch, I.
Swiss Pat. 681 623A, 1993.
1-Chloro-N,N,2-trimethylpropenylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Chloro-N,N,2-trimethylpropenylamine manufacturers
- Product
- 1-Chloro-N,N,2-trimethylpropenylamine 26189-59-3
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 1-Chloro-N,N,2-trimethyl-1-propenylamine 26189-59-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 1-Chloro-N,N,2-trimethyl-1-propenylamine 26189-59-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08