2,3,5,6-Tetrachloropyridine Property

Melting point:

90.5°C

Boiling point:

251.6°C

Density 

2.0309 (rough estimate)

vapor pressure 

3Pa at 25℃

refractive index 

1.6000 (estimate)

Flash point:

188°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

very soluble in Ether,Ethanol

form 

Crystalline

pka

-5.50±0.50(Predicted)

color 

White to Almost white

BRN 

129639

InChIKey

FATBKZJZAHWCSL-UHFFFAOYSA-N

LogP

3.87 at 30℃ and pH7

Surface tension

72.4mN/m at 20.7mg/L and 21.3℃

CAS DataBase Reference

2402-79-1(CAS DataBase Reference)

EPA Substance Registry System

2,3,5,6-Tetrachloropyridine (2402-79-1)

Safety

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38-51/53

Safety Statements 

26-36/37/39-60-61-36

RIDADR 

2811

RTECS 

UT8225000

Hazard Note 

Harmful/Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

2933392000

Hazardous Substances Data

2402-79-1(Hazardous Substances Data)

Toxicity

mouse,LD50,intraperitoneal,1150mg/kg (1150mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LIVER: FATTY LIVER DEGERATIONBEHAVIORAL: ANTIPSYCHOTIC,Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

2,3,5,6-Tetrachloropyridine Chemical Properties,Usage,Production

Uses

2,3,5,6-Tetrachloropyridine is used as a chemical intermediate in the production of chlorpyrifos and triclopyr.

Synthesis

2,3,5,6-Tetrachloropyridine is synthesised in three steps by chemical reaction using 2,3,4,5,6-pentachloropyridine as a raw material. The specific synthesis steps are as follows:
Step (1): 2 parts of pentachloropyridine was dissolved in 200 parts of ethanol at 40 ℃ until 0.6 part of metallic manganese powder was added after the raw material was completely dissolved; 1.3 parts of ammonium acetate, 5 parts of water and 10 parts of ethanol were mixed Uniform dropping, dropping time of 2h; After completion of the dropwise addition, the reaction solution was stirred for 4 hours.
Step (2): add ammonia to adjust the pH value of 8~9, heated to 65 , through 3L / min air 1h reaction was oxidized.
Step (3): Oxidation liquid filtration: The resulting solid was filtered and separated by washing with 20 parts of toluene. Ethanol washed twice, washed twice, after dryingproduct. Products tested by the magnetic content of manganese oxide products, the specific surface area of 53m2 / g, Mn content of 70.90%, CaO content0.0012%, K content 0.0005%, Na content 0.0025%, S content 0.0070%. The XRD pattern of manganese tetroxide and the comparison with the standard map is Mn3O44. Figure 5 (a) and (b) are scanning electron micrographs. It can be seen that the product is a hollow spherical structure. (C) and (d) are transmission electron micrographs, and the hollow structure can be seen and the product is from 10 to 25 nm Grain composition. The filtrate was filtered and the organic solution of the solution of manganese tetrachloride was combined and evaporated to recover the toluene solvent. Then, 10 parts of 5% dilute hydrochloric acid was added at a temperature of 65 ℃ and stirred for 1 h to obtain 2,3,5,6-tetrachloropyridine ; The yield was 99.5%.