ChemicalBook > CAS DataBase List > GSK2894631A

GSK2894631A

Product Name
GSK2894631A
CAS No.
2101626-26-8
Chemical Name
GSK2894631A
Synonyms
GSK2894631A;HPGDS inhibitor 2;GSK-2894631A(HPGDS inhibitor 2);HPGDS inhibitor 2, 10 mM in DMSO;7-(Difluoromethoxy)-N-(trans-4-(2-hydroxypropan-2-yl)cyclohexyl)quinoline-3-carboxamide;7-(difluoromethoxy)-N-[(1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl]quinoline-3-carboxamide;7-(Difluoromethoxy)- N-[trans-4-(1-hydroxy-1-methylethyl)cyclohexyl]-3-quinolinecarboxamide;3-Quinolinecarboxamide, 7-(difluoromethoxy)-N-[trans-4-(1-hydroxy-1-methylethyl)cyclohexyl]-;HPGDS inhibitor2,PGE synthase,Inhibitor,inhibit,HPGDS inhibitor-2,HPGDS inhibitor 2,Prostaglandin E synthase
CBNumber
CB44882154
Molecular Formula
C20H24F2N2O3
Formula Weight
378.41
MOL File
2101626-26-8.mol
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GSK2894631A Property

Boiling point:
572.5±45.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
4°C, away from moisture and light
solubility 
DMSO:150.0(Max Conc. mg/mL);396.39(Max Conc. mM)
form 
Solid
pka
13.22±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0090737
Product name
HPGDSinhibitor2
Purity
99.79%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0090737
Product name
HPGDSinhibitor2
Purity
99.79%
Packaging
10mg
Price
$550
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573475
Product name
GSK-2894631A
Purity
>98%
Packaging
100mg
Price
$1133.9
Updated
2021/12/16
ChemScene
Product number
CS-0090737
Product name
HPGDSinhibitor2
Purity
99.79%
Packaging
50mg
Price
$1650
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573475
Product name
GSK-2894631A
Purity
>98%
Packaging
250mg
Price
$2097.8
Updated
2021/12/16
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GSK2894631A Chemical Properties,Usage,Production

Uses

HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM[1].

References

[1] Deaton DN, et al. The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1456-1478. DOI:10.1016/j.bmc.2019.02.017

GSK2894631A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2894631A Suppliers

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2101626-26-8, GSK2894631ARelated Search:

GSK3008348 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate GSK2983559 cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate GSK3175047 GSK2982772 GSK-2881078 N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide GSK3145095 GSK3039294

  • HPGDS inhibitor 2
  • GSK2894631A
  • 3-Quinolinecarboxamide, 7-(difluoromethoxy)-N-[trans-4-(1-hydroxy-1-methylethyl)cyclohexyl]-
  • 7-(Difluoromethoxy)- N-[trans-4-(1-hydroxy-1-methylethyl)cyclohexyl]-3-quinolinecarboxamide
  • HPGDS inhibitor2,PGE synthase,Inhibitor,inhibit,HPGDS inhibitor-2,HPGDS inhibitor 2,Prostaglandin E synthase
  • GSK-2894631A(HPGDS inhibitor 2)
  • 7-(Difluoromethoxy)-N-(trans-4-(2-hydroxypropan-2-yl)cyclohexyl)quinoline-3-carboxamide
  • 7-(difluoromethoxy)-N-[(1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl]quinoline-3-carboxamide
  • HPGDS inhibitor 2, 10 mM in DMSO
  • 2101626-26-8