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2-ISOPROPYLANILINE

Product Name
2-ISOPROPYLANILINE
CAS No.
643-28-7
Chemical Name
2-ISOPROPYLANILINE
Synonyms
O-CUMIDINE;AKOS 91140;O-AMINOCUMENE;2-AMINOCUMENE;ORTHO CUMIDINE;AKOS BBS-00003573;O-ISOPROPYLANILINE;o-isopropyl-anilin;2-ISOPROPYLANILINE;Aniline, o-isopropyl-
CBNumber
CB4490526
Molecular Formula
C9H13N
Formula Weight
135.21
MOL File
643-28-7.mol
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2-ISOPROPYLANILINE Property

Melting point:
-6.87°C (estimate)
Boiling point:
112-113 °C/18 mmHg (lit.)
Density 
0.955 g/mL at 25 °C (lit.)
vapor pressure 
0.05 mm Hg ( 20 °C)
refractive index 
n20/D 1.548(lit.)
Flash point:
204 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Liquid
pka
4.42±0.10(Predicted)
color 
Clear pale yellow to orange or brown
Specific Gravity
0.966
Water Solubility 
Insoluble in water.
Sensitive 
Light Sensitive
BRN 
636283
InChI
1S/C9H13N/c1-7(2)8-5-3-4-6-9(8)10/h3-7H,10H2,1-2H3
InChIKey
YKOLZVXSPGIIBJ-UHFFFAOYSA-N
SMILES
CC(C)c1ccccc1N
CAS DataBase Reference
643-28-7(CAS DataBase Reference)
EPA Substance Registry System
o-Isopropylaniline (643-28-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
BY4200000
TSCA 
TSCA listed
HS Code 
29214990
Storage Class
10 - Combustible liquids
Hazard Classifications
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
268887
Product name
2-Isopropylaniline
Purity
97%
Packaging
5ml
Price
$24.95
Updated
2025/07/31
Sigma-Aldrich
Product number
268887
Product name
2-Isopropylaniline
Purity
97%
Packaging
100ml
Price
$95.2
Updated
2025/07/31
TCI Chemical
Product number
I0318
Product name
2-Isopropylaniline
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
I0318
Product name
2-Isopropylaniline
Purity
>98.0%(GC)(T)
Packaging
250mL
Price
$116
Updated
2025/07/31
TRC
Product number
I824170
Product name
o-Isopropylaniline
Packaging
100g
Price
$195
Updated
2021/12/16
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2-ISOPROPYLANILINE Chemical Properties,Usage,Production

Chemical Properties

Clear pale yellow liquid

Uses

Reagent in determination of tungsten.

Uses

2-Isopropylaniline is used in the synthesis of a colorless amine-coordinated zinc complex. The reactions of 1,1?-bis(hydroxymethyl)ferrocene with 2-isopropylaniline, in the presence of a catalyst [RuCl2(PPh3)3], was studied

Definition

ChEBI: 2-Isopropylaniline is an alkylbenzene.

Synthesis Reference(s)

[1] Dr. Huaibo Zhao,  Prof. Daniele Leonori.“Minimization of Back-Electron Transfer Enables the Elusive sp3 C−H Functionalization of Secondary Anilines.” Angewandte Chemie International Edition 60 14 (2021): 7669–7674.

General Description

The reactions of 1,1′-bis(hydroxymethyl)ferrocene with 2-isopropylaniline, in the presence of a catalyst [RuCl2(PPh3)3], was studied.

Synthesis

Charge a dry tube equipped with a stirring bar with Ir(dtbbpy)(ppy)2PF6 (4 mg, 4 μmol, 2 mol%), Co(dmgH)(dmgH2)Cl2 (11 mg, 0.03 mmol, 15 mol%), and 2-isopropyl-N-methylaniline (30 mg, 0.20 mmol, 1.0 equiv.); Cap the tube with a Supelco aluminium crimp seal with septum (PTFE/butyl); Evacuate the reaction mixture under high vacuum and backfill with N2 (x 3); Add degassed CH3CN (2.0 mL, 0.1 M), 2-isopropyl-N-methylaniline (30 mg, 0.20 mmol) and Et3N (28 μL, 0.20 mmol, 1.0 equiv.) sequentially to the reaction mixture; Cool the reaction mixture to -78°C and degas by three cycles of freeze, pump (5 min), backfill (with N2), and thaw;
Degas the reaction mixture thoroughly; Seal the vial with parafilm and place approximately 4 cm from blue LEDs; Switch on the blue LEDs and stir the reaction mixture under irradiation without fan for 24 hours; Open the tube and dilute the reaction mixture with H2O (10 mL) and EtOAc (10 mL); Separate the layers and extract the aqueous layer with EtOAc (2 x 10 mL); Wash the combined organic layers with brine (10 mL); Dry the mixture over Na2SO4; Filter the residue and evaporate; Purify the crude product by flash column chromatography on silica gel with hexane-EtOAc to obtain 2-isopropylaniline.[1] 

2-ISOPROPYLANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

2,6-Diisopropylaniline
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2-ISOPROPYLANILINE Suppliers

Americas 1 Belgium 4 China 150 Europe 1 France 1 Germany 5 India 15 Japan 3 Switzerland 3 United Kingdom 13 United States 34 Global 230
Shanghai Taijilin Industrial Co., Ltd.
Tel
02150630626 17717886015
Fax
021-50563898
Email
kate@tajilin.com
Country
China
ProdList
1296
Advantage
58
LEWOO PHARMATECH (SHANGHAI) CO.,LTD
Tel
15800805830
Email
miao@lewoopharma.com.cn
Country
China
ProdList
934
Advantage
58
Jinan Gaochun Pharmaceutical Technology Co., Ltd.
Tel
13287077755 13044030397
Email
171790338@qq.com
Country
China
ProdList
11
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
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View Lastest Price from 2-ISOPROPYLANILINE manufacturers

Career Henan Chemical Co
Product
2-ISOPROPYLANILINE 643-28-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2020-01-08

643-28-7, 2-ISOPROPYLANILINERelated Search:

2-Isopropylphenol STRYCHNINE 2,6-Diisopropylaniline BASIC YELLOW 11 2-METHYL-6-ISOPROPYLANILINE,2-METHYL-6-ISOPROPYLANILINE 2,4,6-TRI-TERT-BUTYLANILINE 2,3,3-Trimethylindolenine 5-Chloro-2-methylene-1,3,3-trimethylindoline 2,5-DI-TERT-BUTYLANILINE 1,3,3-Trimethyl-2-methyleneindoline 2,6-Diisopropylphenyl isocyanate 10,11-Dimethoxystrychnine 2,4,6-TRI-TERT-BUTYLNITROSOBENZENE 2,3-DIMETHYLINDOLINE BASIC ORANGE 21 2,4,6-TRI-TERT-BUTYLNITROBENZENE 3-METHYL-4-ISOPROPYLANILINE HYDROCHLORIDE,3-METHYL-4-ISOPROPYLANILINE HYDROCHLORIDE 2,4-Dimethyl-3-(1-methylethyl)benzenamine

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