2-HYDROXYADENOSINE

Product Name: 2-HYDROXYADENOSINE
CAS No.: 1818-71-9
Chemical Name: 2-HYDROXYADENOSINE
Synonyms: ISOGUANOSINE;iso-Gr;CROTONOSIDE;2-Hydroxydenosine;6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-2H-purin-2-one;NSC 12161;CROTONOSID;lsoguanosine;2-Oxoadenosine;ISOGUANOSINE(P)
CBNumber: CB4491235
Molecular Formula: C10H13N5O5
Formula Weight: 283.24
MOL File: 1818-71-9.mol

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2-HYDROXYADENOSINE Property

storage temp.: -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
Density: 2.25±0.1 g/cm3(Predicted)
Melting point:: 237-241 °C(Solv: water (7732-18-5))
pka: 8.25±0.40(Predicted)
color: White to off-white

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00322
Product name: Crotonoside
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $400
Updated: 2023/06/20

Sigma-Aldrich

Product number: SMB00322
Product name: Crotonoside
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $643
Updated: 2023/01/07

Cayman Chemical

Product number: 28219
Product name: Crotonoside
Packaging: 1mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 28219
Product name: Crotonoside
Packaging: 25mg
Price: $1163
Updated: 2024/03/01

Cayman Chemical

Product number: 28219
Product name: Crotonoside
Packaging: 5mg
Price: $324
Updated: 2024/03/01

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2-HYDROXYADENOSINE Chemical Properties,Usage,Production

Description

Crotonoside is a purine analogue that is structurally similar to pyrazole, which also inhibits the polymerase chain reaction in vitro. Crotonoside has been shown to be an inhibitor of the polymerase chain reaction in vitro, but it is unclear if this activity will translate to in vivo models.

Uses

2-?Hydroxyadenosine is an isoquinoline alkaloid displaying anticancer activity.

Definition

ChEBI: Crotonoside is a purine nucleoside.

in vivo

Crotonoside(intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily) induces a significant antitumor activity and inhibited xenograft tumor progress as compared to treatment with vehicle^[1].

Animal Model:	NOD-SCID mice with MV4-11 cells^[1]
Dosage:	70 mg/kg, 35 mg/kg
Administration:	Intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily
Result:	Produced significant AML tumor inhibition rates of 93.5% at 70 mg/kg.

target

Adenosine Receptor

IC 50

FLT3; HDAC3; HDAC6

2-HYDROXYADENOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXYADENOSINE Suppliers

China 197 Finland 1 India 3 United Kingdom 3 United States 19 Global 223

Hongene Biotech Corporation

Tel: 021-64757213
Fax: 86-21-64700613
Email: info@hongene.com
Country: China
ProdList: 672
Advantage: 61

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

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Email: sales@meilune.com
Country: China
ProdList: 4729
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

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Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
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Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

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View Lastest Price from 2-HYDROXYADENOSINE manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Regadenoson Impurity 17 1818-71-9
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-08

Shanghai Standard Technology Co., Ltd.

Product: Crotonoside 1818-71-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-15

Career Henan Chemical Co

Product: Crotonoside 1818-71-9
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-25

1818-71-9, 2-HYDROXYADENOSINERelated Search:

Croverin Xanthiside 12-O-Tiglylphorbol-13 -isobutyrate 4-ethoxy-1,1,1-trichloro-3-buten-2-one Ethyl 3,3-Diethoxypropionate 2-Chloroadenosine Propanoicacid,2-formyl-3-oxo-,ethylester 2-Hydrazinoadenosine Ethyl pyrazole-4-carboxylate REGADENOSON 2-CHLORO-6-AMINO-9-(2',3',5'-TRI-O-ACETYL-?-D-RIBOFURANOSYL)PURINE ISOQUERCITRIN Asiaticoside PINOCEMBRIN Vitexin 2-HYDROXYADENOSINE Isoguanosine Triacetate ISOGUANOSINE HYDRATE

Adenosine, 2,3-dihydro-2-oxo-

Regadenoson Impurity 17

6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-2H-purin-2-one

Crotonoside, 98%, from Croton tiglium L.

Adenosine Impurity 6

1,2-dihydro-2-oxo-adenosin

1,2-dihydro-2-oxoadenosine

6-amino-9-beta-d-ribofuranosyl-9h-purin-2-o

isoguanineriboside

2-HYDROXYADENOSINE

ISOGUANOSINE(P)

2-Hydroxydenosine

CROTONOSID

CROTONOSIDE

ISOGUANOSINE

ISOGUANOSINE RIBOSIDE

2(1H)-Oxoadenosine

6-Amino-9-β-D-ribofuranosyl-9H-purin-2(1H)-one

NSC 12161

9-(b-D-Ribofuranosyl)isoguanine

2,3-dihydro-2-oxo-Adenosine

iso-Gr

Crotonoside >=95% (HPLC)

2-?Hydroxyadenosine DISCONTINUED. Please see I819500

9-(β-D-Ribofuranosyl)isoguanine

(2R,3R,4S,5R)-2-(6-Amino-2-hydroxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

2-Oxoadenosine

lsoguanosine

Crotonoside, 10 mM in DMSO

1818-71-9

C10H13O5N5

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract