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MAST CELL DEGRANULATING PEPTIDE

Product Name
MAST CELL DEGRANULATING PEPTIDE
CAS No.
32908-73-9
Chemical Name
MAST CELL DEGRANULATING PEPTIDE
Synonyms
MCD;isulfide);MCD PEPTIDE;Peptide 401;IKCNCKRHVIKPHICRKICGKN-NH2;MCD PEPTIDE (APIS MELLIFERA);MAST CELL DEGRANULATING PEPTIDE;MAST CELL DEGRANULATING (MCD) PEPTIDE;mastcelldegranulatingpeptide(honeybee);MCD-PEPTIDE (HONEYBEE, APIS MELLIFERA)
CBNumber
CB4493264
Molecular Formula
C110H192N40O24S4
Formula Weight
2587.24
MOL File
32908-73-9.mol
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MAST CELL DEGRANULATING PEPTIDE Property

Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
Sequence
Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)
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Safety

WGK Germany 
3
RTECS 
OQ5980000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7079
Product name
Peptide401
Purity
98.29%
Packaging
500ug
Price
$336
Updated
2021/12/16
Biorbyt Ltd
Product number
orb99641
Product name
Mast Cell Degranulating peptide
Purity
Greater than 98 % purified
Packaging
0.5mg
Price
$408
Updated
2021/12/16
ChemScene
Product number
CS-7079
Product name
Peptide401
Purity
98.29%
Packaging
1mg
Price
$576
Updated
2021/12/16
Biorbyt Ltd
Product number
orb99642
Product name
Mast Cell Degranulating peptide
Purity
Greater than 98 % purified
Packaging
1mg
Price
$595
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0002440
Product name
MAST CELL DEGRANULATING PEPTIDE
Purity
95.00%
Packaging
0.5MG
Price
$726.73
Updated
2021/12/16
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MAST CELL DEGRANULATING PEPTIDE Chemical Properties,Usage,Production

Uses

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

Biological Activity

Peptide 401 is a potent mast cell degranulation peptide derived from bee venom that inhibits vascular permeability.

in vivo

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125 I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, ie, hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcut aneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5-hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents.

target

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IC 50

serotonin; Histamine Receptor

References

[1] Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92. DOI:10.1111/j.1476-5381.1974.tb09613.x
[2] Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4. DOI:10.1111/j.1476-5381.1990.tb14707.x

MAST CELL DEGRANULATING PEPTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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MAST CELL DEGRANULATING PEPTIDE Suppliers

China 67 Switzerland 1 United States 7 Global 75
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021-54306202 13764082696
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China
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China
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zhao.xu@njpeptide.com
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China
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View Lastest Price from MAST CELL DEGRANULATING PEPTIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
MAST CELL DEGRANULATING PEPTIDE 32908-73-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-13
Career Henan Chemical Co
Product
MAST CELL DEGRANULATING PEPTIDE 32908-73-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16

32908-73-9, MAST CELL DEGRANULATING PEPTIDERelated Search:

3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE ECHISTATIN PHOSPHOLIPASE A2 Desacetylcinobufagin 19-Hydroxybufalin CHLOROTOXIN MAST CELL DEGRANULATING PEPTIDE HR-1 SHK MAST CELL DEGRANULATING PEPTIDE HR-2 MAS 7 MU-CONOTOXIN GIIIA Polistes mastoparan MASTOPARAN 17 ENTEROTOXIN STP (E COLI) NA CYS-GLY MAST CELL DEGRANULATING PEPTIDE MAST CELL DEGRANULATING PEPTIDE

  • H-ILE-LYS-+CYS-ASN-++CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-+CYS-ARG-LYS- ILE-++CYS-GLY-LYS-ASN-NH2
  • H-ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2
  • H-ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2 (RANDOM CYCLIZATION)
  • IKCNCKRHVIKPHICRKICGKN-NH2
  • ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2
  • MAST CELL DEGRANULATING PEPTIDE
  • MAST CELL DEGRANULATING PEPTIDE (APIS MELLIFERA)
  • MAST CELL DEGRANULATING (MCD) PEPTIDE
  • MCD PEPTIDE
  • MCD PEPTIDE (APIS MELLIFERA)
  • MCD
  • isulfide)
  • mastcelldegranulatingpeptide(honeybee)
  • mastcelldegranulatingpeptide(honeybeereduced)cyclic(3-15),(5-19)-bis(d
  • MCD-PEPTIDE (HONEYBEE, APIS MELLIFERA)
  • L-Ile-L-Lys-L-Cys(1)-L-Asn-L-Cys(2)-L-Lys-L-Arg-L-His-L-Val-L-Ile-L-Lys-L-Pro-L-His-L-Ile-L-Cys(1)-L-Arg-L-Lys-L-Ile-L-Cys(2)-Gly-L-Lys-L-Asn-NH2
  • Peptide 401
  • Mast Cell Degranulating (MCD) Peptide Peptide 401
  • L-Aspartamide, L-isoleucyl-L-lysyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-arginyl-L-histidyl-L-valyl-L-isoleucyl-L-lysyl-L-prolyl-L-histidyl-L-isoleucyl-L-cysteinyl-L-arginyl-L-lysyl-L-isoleucyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→15),(5→19)-bis(disulfide)
  • 32908-73-9
  • C110H192N40O24S4
  • Voltage-gated Ion Channels
  • Ion Channels
  • Potassium Channel Modulators
  • Monovalent Ion Channels
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology

    • serotonin

    Histamine Receptor