3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE

Product Name: 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
CAS No.: 9040-59-9
Chemical Name: 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
Synonyms: PDE 3B;EC 3.1.4.17;Phosphodiesterase 3B;(4-Nitrobenzyl)arsonic acid;Phosphodiesterasefrombovinebrain;Phosphodiesterase 3B, Recombinant;3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE;PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE;Phosphodiesterase, cyclic 3',5'-nucleotide;Phosphodiesterase 3A from Human, Recombinant
CBNumber: CB2437361
Formula Weight: 0
MOL File: Mol file

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3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Property

storage temp.: -20°C
form: lyophilized powder

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P9529
Product name: Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain
Purity: 15-30?units/mg protein (in the presence of 0.03 mM Ca2+ and a saturating level (10 units per ml) of calmodulin (P2277)), lyophilized powder
Packaging: 1unit
Price: $471
Updated: 2022/05/15

American Custom Chemicals Corporation

Product number: ENZ0000358
Product name: 3',5'-CYCLIC-NUCLEOTIDE-5'-NUCLEOTIDOHYDROLASE
Purity: 95.00%
Packaging: 5MG
Price: $500.81
Updated: 2021/12/16

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3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Chemical Properties,Usage,Production

Uses

For use in calmodulin (P 0270) assay. Activity is reduced to <50% without calmodulin present.

Uses

Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain has been used to assay the protein activator, calmodulin and in in vitro adenylate cyclase assay.

General Description

Phosphodiesterase (PDE1) exists in two isoforms -PDE1A2 and PDE1B1. The enzyme has a role in the complex interaction between cyclic nucleotides and Ca²⁺ second-messenger systems.

Biochem/physiol Actions

Hydrolyzes the 3′,5′-phosphodiester bond in cyclic nucleotide monophosphates, such as cAMP and cGMP, to the corresponding nucleotide 5′-monophosphate.

Clinical Use

Phosphodiesterase-3 (PDE3) is an enzyme responsible for degradation of cAMP to AMP in platelets and blood vessels. Selective cAMP PDE3 inhibitors, such as dipyridamole and cilostazol , inhibit the degradation of cAMP, thereby increasing cellular concentration of cAMP and leading to inhibition of platelet aggregation and vasodilation.

3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Preparation Products And Raw materials

Raw materials

Preparation Products

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3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Suppliers

China 12 Germany 1 Switzerland 2 United States 6 Global 21

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9040-59-9, 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASERelated Search:

Benzyl isocyanide DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Cupric acetylacetonate Ethyl isocyanoacetate Aluminum acetylacetonate METHYL ISOCYANOACETATE SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE Ferric acetylacetonate N-BUTYLISOCYANIDE Tosylmethyl isocyanide PHENYLSELENOL COBALT(II) ACETYLACETONATE TERT-BUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)

3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE

phosphodiesterase 3':5'-cyclic*nucleotide crude C

Phosphodiesterase, cyclic 3',5'-nucleotide

PHOSPHODIESTERASE 3':5'-CYCLIC*NUCLEOTID E FROM BOVI

PHOSPHODIESTERASE 3':5'-CYCLIC*NUCLEOTID E CRUDE COM

Phosphodiesterasefrombovinebrain

3',5'-cyclic-nucleotide 5'-nucleotidohydrolase from bovine brain

phosphodiesterase, 3',5'-cyclic-nucleotide-specific from bovine brain

CYCLIC 3'',5''-NUCLEOTIDE PHOSPHODIESTERASE (FROM BEEF HEART)

phosphodiesterase, 3',5'-cyclic-nucleotide-specific

PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from porcine brain

Phosphodiesterase, 3μ,5μ-Cyclic Nucleotide, Activator-deficient from porcine brain

PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from bovine brain

PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from bovine heart

Phosphodiesterase 3μ,5μ-Cyclic Nucleotide Activator-deficient from bovine heart

PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE

EC 3.1.4.17

PDE 3B

Phosphodiesterase 3B

Phosphodiesterase 3B, Recombinant

Native Bovine Phosphodiesterase 3,5-Cyclic Nucleotide Activator-deficient

Native Bovine Phosphodiesterase, 3,5-cyclic-nucleotide-specific

Native Porcine Phosphodiesterase, 3,5-Cyclic Nucleotide, Activator-deficient

Phosphodiesterase 3A from Human, Recombinant

Phosphodiesterase, 3',5'-cyclic-nucleotide-specific from bovine brain 15-30 units/mg protein (in the presence of 0.03 mM Ca2+ and a saturating level (10 units per ml) of calmodulin (P2277)), lyophilized powder

(4-Nitrobenzyl)arsonic acid

9040-59-9

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Cyclic Nucleotide Metabolism

G Proteins and Cyclic Nucleotides

Enzymes