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3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE

Product Name
3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
CAS No.
9040-59-9
Chemical Name
3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
Synonyms
PDE 3B;EC 3.1.4.17;Phosphodiesterase 3B;(4-Nitrobenzyl)arsonic acid;Phosphodiesterasefrombovinebrain;Phosphodiesterase 3B, Recombinant;3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE;PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE;Phosphodiesterase, cyclic 3',5'-nucleotide;Phosphodiesterase 3A from Human, Recombinant
CBNumber
CB2437361
Formula Weight
0
MOL File
Mol file
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3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Property

storage temp. 
-20°C
form 
lyophilized powder
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P9529
Product name
Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain
Purity
15-30?units/mg protein (in the presence of 0.03 mM Ca2+ and a saturating level (10 units per ml) of calmodulin (P2277)), lyophilized powder
Packaging
1unit
Price
$471
Updated
2022/05/15
American Custom Chemicals Corporation
Product number
ENZ0000358
Product name
3',5'-CYCLIC-NUCLEOTIDE-5'-NUCLEOTIDOHYDROLASE
Purity
95.00%
Packaging
5MG
Price
$500.81
Updated
2021/12/16
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3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Chemical Properties,Usage,Production

Uses

For use in calmodulin (P 0270) assay. Activity is reduced to <50% without calmodulin present.

Uses

Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain has been used to assay the protein activator, calmodulin and in in vitro adenylate cyclase assay.

General Description

Phosphodiesterase (PDE1) exists in two isoforms -PDE1A2 and PDE1B1. The enzyme has a role in the complex interaction between cyclic nucleotides and Ca2+ second-messenger systems.

Biochem/physiol Actions

Hydrolyzes the 3′,5′-phosphodiester bond in cyclic nucleotide monophosphates, such as cAMP and cGMP, to the corresponding nucleotide 5′-monophosphate.

Clinical Use

Phosphodiesterase-3 (PDE3) is an enzyme responsible for degradation of cAMP to AMP in platelets and blood vessels. Selective cAMP PDE3 inhibitors, such as dipyridamole and cilostazol , inhibit the degradation of cAMP, thereby increasing cellular concentration of cAMP and leading to inhibition of platelet aggregation and vasodilation.

3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Preparation Products And Raw materials

Raw materials

Preparation Products

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3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Suppliers

China 12 Germany 1 Switzerland 2 United States 6 Global 21
SIGMA-RBI
Tel
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Country
Switzerland
ProdList
6896
Advantage
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Alexis Corporation
Tel
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Fax
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Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
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9040-59-9, 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASERelated Search:

Benzyl isocyanide DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Cupric acetylacetonate Ethyl isocyanoacetate Aluminum acetylacetonate METHYL ISOCYANOACETATE SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE Ferric acetylacetonate N-BUTYLISOCYANIDE Tosylmethyl isocyanide PHENYLSELENOL COBALT(II) ACETYLACETONATE TERT-BUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)

  • 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
  • 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE
  • phosphodiesterase 3':5'-cyclic*nucleotide crude C
  • Phosphodiesterase, cyclic 3',5'-nucleotide
  • PHOSPHODIESTERASE 3':5'-CYCLIC*NUCLEOTID E FROM BOVI
  • PHOSPHODIESTERASE 3':5'-CYCLIC*NUCLEOTID E CRUDE COM
  • Phosphodiesterasefrombovinebrain
  • 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase from bovine brain
  • phosphodiesterase, 3',5'-cyclic-nucleotide-specific from bovine brain
  • CYCLIC 3'',5''-NUCLEOTIDE PHOSPHODIESTERASE (FROM BEEF HEART)
  • phosphodiesterase, 3',5'-cyclic-nucleotide-specific
  • PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from porcine brain
  • Phosphodiesterase, 3μ,5μ-Cyclic Nucleotide, Activator-deficient from porcine brain
  • PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from bovine brain
  • PDE, 3μ,5μ-Cyclic-nucleotide 5μ-nucleotidohydrolase from bovine heart
  • Phosphodiesterase 3μ,5μ-Cyclic Nucleotide Activator-deficient from bovine heart
  • PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE
  • EC 3.1.4.17
  • PDE 3B
  • Phosphodiesterase 3B
  • Phosphodiesterase 3B, Recombinant
  • Native Bovine Phosphodiesterase 3,5-Cyclic Nucleotide Activator-deficient
  • Native Bovine Phosphodiesterase, 3,5-cyclic-nucleotide-specific
  • Native Porcine Phosphodiesterase, 3,5-Cyclic Nucleotide, Activator-deficient
  • Phosphodiesterase 3A from Human, Recombinant
  • Phosphodiesterase, 3',5'-cyclic-nucleotide-specific from bovine brain 15-30 units/mg protein (in the presence of 0.03 mM Ca2+ and a saturating level (10 units per ml) of calmodulin (P2277)), lyophilized powder
  • (4-Nitrobenzyl)arsonic acid
  • 9040-59-9
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Cyclic Nucleotide Metabolism
  • G Proteins and Cyclic Nucleotides
  • Enzymes