Description
ChemicalBook > CAS DataBase List > D-(+)-Glucono-1,5-lactone

D-(+)-Glucono-1,5-lactone

Description
Product Name
D-(+)-Glucono-1,5-lactone
CAS No.
90-80-2
Chemical Name
D-(+)-Glucono-1,5-lactone
Synonyms
GLUCONOLACTONE;GDL;GLUCONO-DELTA-LACTONE;D-GLUCONO-1,5-LACTONE;Glucosactone;(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-one;DELTA-GLUCONOLACTONE;Glucolactone;Glucono;Gluconic lactone
CBNumber
CB4494337
Molecular Formula
C6H10O6
Formula Weight
178.14
MOL File
90-80-2.mol
More
Less

D-(+)-Glucono-1,5-lactone Property

Melting point:
160 °C (dec.)(lit.)
alpha 
65 º (c=1,H2O)
Boiling point:
230.35°C (rough estimate)
Density 
0.6
bulk density
750kg/m3
refractive index 
63.5 ° (C=10, H2O)
storage temp. 
Sealed in dry,Room Temperature
solubility 
590g/l Hydrolysis
form 
Crystalline Powder
pka
12.06±0.60(Predicted)
color 
White to off-white
Odor
wh. cryst. powd., pract. odorless
PH
3.6 (10g/l, H2O, 20℃)
biological source
microbial
Water Solubility 
500 g/L (20 ºC)
Merck 
14,4457
BRN 
83286
LogP
-2.38
CAS DataBase Reference
90-80-2(CAS DataBase Reference)
NIST Chemistry Reference
D-Gluconic acid, «delta»-lactone(90-80-2)
EPA Substance Registry System
.delta.-Gluconolactone (90-80-2)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
21-36/38-46-62-63
Safety Statements 
24/25-53-36/37-26-25
WGK Germany 
3
RTECS 
LZ5184000
21
TSCA 
Yes
HS Code 
29322090
Hazardous Substances Data
90-80-2(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3656
Product name
Gluconolactone
Purity
certified reference material, pharmaceutical secondary standard
Packaging
200MG
Price
$152
Updated
2025/07/31
Sigma-Aldrich
Product number
G2164
Product name
Gluconolactone
Purity
meets USP testing specifications
Packaging
1kg
Price
$108
Updated
2025/07/31
Sigma-Aldrich
Product number
8.43794
Product name
D-(+)-Glucono-delta-lactone
Purity
for synthesis
Packaging
100g
Price
$63.6
Updated
2025/07/31
Sigma-Aldrich
Product number
347425
Product name
Gluconolactone - CAS 90-80-2 - Calbiochem
Purity
An oxidation product of glucose by glucose oxidase.
Packaging
500g
Price
$119
Updated
2025/07/31
Sigma-Aldrich
Product number
1294150
Product name
Gluconolactone
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$490
Updated
2025/07/31
More
Less

D-(+)-Glucono-1,5-lactone Chemical Properties,Usage,Production

Description

Delta-Gluconolactone (GDL) is a lactone of the D-gluconate. It is a natural constituent of many foods. It can be found in honey, fruit juices, wine and many-fermented products1-3. It is used as a food additive with the E number E575 used as a sequestrant, an acidifier (it lower the pH and also help preserve the food from deterioration by enzymes and organisms), or a curing, pickling, or leavening agent. GDL has been marketed for use in feta cheese. GDL is neutral, but hydrolyses in water to gluconic acid that is acidic, adding a tangy taste to foods, though it has roughly a third of the sourness of citric acid. It can be used as nutritional supplement in beverage such as in Instant Drinks, Syrups, RTD Tea and Coffee, Sports and Energy Drinks, Waters.

Description

Glucono delta-lactone (C6H10O6), molecular weight 178.14, is an inner ester of gluconic acid. Commonly named gluconolactone, other synonyms include D-gluconic acid delta-lactone, D-glucono- 1, 5-lactone, and D-delta-gluconolactone. Some of its earliest uses as a food ingredient were as a flavoring (e.g., sherbets) and to reduce fat absorption in doughnuts and cones. Glucono deltalactone tastes sweet initially and has a slightly acid-aftertaste.

Chemical Properties

Powder

Uses

Geogard(R)Ultra is a synergistic blend of gluconolactone and sodium benzoate. This blend provides broad spectrum protection against product spoilage in a variety of personal care formulations. Product Data Sheet

Uses

A lactone (cyclic ester) of D-gluconic acid used as a used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent.

Uses

a product of the oxidation of glucose by glucose oxidase

Uses

gluconolactone is used in cosmetics for its anti-acne properties. It can also help improve skin hydration given its water-binding ability. In addition, formulators may select gluconolactone for its action as a product stabilizer (chelating agent). Some studies indicate potential free-radical scavenging capacities as well. These properties would make it particularly relevant for use in making anti-aging, moisturizing, and possibly sun care products.

Uses

(GDL) An acidulant. It hydrolyzes to form gluconic acid in water solution and thereby creates the desired pH. The rate of acid formation is affected by temperature, concentration, and the pH of the solution. It has low acid release at room temperature and accelerated conversion into gluconic acid at high temperatures. It is readily soluble with a solubility of 59 g in 100 ml of water at 20°C. It functions as a leavening agent, acidulant, curing and pickling agent, and pH control agent. It is comparatively less tart/sour than other food acids. It is used in baked goods, fish products, desserts, and dressings.

Uses

D-glucono-1,5-lactone is the lactone derivative of D-gluconic acid. D-glucono-1,5-lactone is widely used as a food additive to achieve a curing, pickling or leavening effect.

Uses

Component of many cleaning cmpds because of the sequestering ability of the gluconate radical which remains active in alk solutions; in the dairy industry to prevent milkstone; in breweries to prevent beerstone; as latent acid catalyst for acid colloid resins, particularly in textile printing; as a coagulant for tofu.

Preparation

Glucono delta-lactone is prepared commercially by the oxidation of glucose with bromine water.

Definition

ChEBI: D-glucono-1,5-lactone is an aldono-1,5-lactone obtained from D-gluconic acid. It has a role as an animal metabolite and a mouse metabolite. It is a gluconolactone and an aldono-1,5-lactone. It is functionally related to a D-gluconic acid.

General Description

Gluconolactone is a non-toxic component of the skin. It has anti-oxidant and free radical scavenging effects. Gluconolactone has antiaging and skin-firming properties. It acts as a?β-glucosidase inhibitor. Gluconolactone stimulates cellulase gene expression.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Glucono-d-lactone increased the doubling time and activated enzymes involved in the oxidative pentose phosphate pathway of Saccharomyces cerevisiae.

Safety Profile

Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise Dglucono-lactone from ethylene glycol monomethyl ether and dry for 1hour at 110o. It can be freed from other sugars via a column of Celite and charcoal (750g of each, 90 x 7.5cm) which is washed with 0.01N formic acid until the pH of the wash is equal to that of the entering acid. The lactone is applied in H2O and eluted with 0.01N formic acid (7L), then eluted with 7.5% EtOH/0.01N formic acid (8L), then 15% EtOH/0.01N formic acid (8L) which removes pentose and isomaltose (the optical rotation of the eluates are used for sugar detection) and finally elution with aqueous formic acid provides glucolactone which is obtained by evaporating or freeze drying. Its solubility in H2O is 60% and 1% in EtOH. A solution in H2O is slightly acidic, and the lactone dissolves in an equivalent of aqueous NaOH to form sodium D-gluconate [527-07-1] M 218.1, m 2002 0 6o(dec), [ ] D 25 +12o (c 10, H2O), pK2 5 3.6. [cf p 553, Smith & Whelan Biochemical Preparations 10 127 1963, Beilstein 3 IV 1255.]

More
Less

D-(+)-Glucono-1,5-lactone Suppliers

Wisdom Drugs Co., Ltd.
Tel
18261161868
Email
527536256@qq.com
Country
China
ProdList
297
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
TRL Bioscience Co., Ltd.
Tel
021-54822871 13817743194
Fax
021-54827552
Email
info@shtrl.com
Country
China
ProdList
93
Advantage
62
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2744
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Qingdao Free Trade Zone United International Co.,Ltd.
Tel
0532-83893697 18561902820
Fax
83893695
Email
sissili@unitedint.com
Country
China
ProdList
352
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5158
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Simagchem Corp.
Tel
86 592 2680277
Fax
0086 592 2680237
Email
sale@simagchem.com
Country
China
ProdList
430
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
Advantage
66
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1972
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3853
Advantage
58
Shanghai GaoLang Chemical Technology Co., Ltd.
Tel
021-57340939 18017297327
Fax
021-37210791
Email
sales@gaolangchemical.com
Country
China
ProdList
892
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
More
Less

View Lastest Price from D-(+)-Glucono-1,5-lactone manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.
Product
Glucono-Delta-Lactone 90-80-2
Price
US $1200.00-1100.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
1000T/M
Release date
2025-08-06
Nexal Inc
Product
Glucono Delta Lactone 90-80-2
Price
US $9.00/KG
Min. Order
1000KG
Purity
≥99.0%
Supply Ability
200 tons
Release date
2025-07-10
WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-(+)-Glucono-1,5-lactone 90-80-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
5000kg/month
Release date
2021-10-28

90-80-2, D-(+)-Glucono-1,5-lactoneRelated Search:


  • Gluconolactone - CAS 90-80-2 - Calbiochem
  • Glucono Delta Lactone, Glucono Delta Lactone powder
  • Cagliflozin Impurity 8
  • delta-Gluconolactone in stock GMP Factory
  • 1,2,3,4,5-PENTAHYDROXYCAPROIC ACID DELTA-LACTONE
  • DELTA-GLUCURONOLACTONE
  • DELTA-GLUCONOLACTONE
  • D(+)-DEXTRONIC ACID DELTA-LACTONE
  • D-GLUCONIC ACID LACTONE
  • D-(+)-GLUCONO-1,5-LACTONE
  • D-GLUCONO-1,5-LACTONE
  • D(+)-GLUCONIC ACID DELTA-LACTONE
  • D-GLUCONIC ACID DELTA-LACTONE
  • D-GLUCONIC ACID-D-LACTONE
  • D-GLUCONO-D-LACTONE
  • D-GLUCONLACTONE
  • D-(+)-GLUCONO-DELTA-LACTONE
  • D-GLUCONO DELTA-LACTONE
  • GLUCONOLACTONE
  • GLUCONO-D-LACTONE
  • GLUCONO-DELTA-LACTONE
  • GLUCONO-1,5-LACTONE
  • GLUCONIC-D-LACTONE
  • GLUCONIC ANHYDRIDE
  • GDL
  • GLUCONIC ACID, ANHYDRIDE
  • GLUCONIC ACID D-LACTONE, D-(+)-
  • GLUCONIC ACID DELTA-LACTONE
  • beta-glucono-1,5-lactone
  • D(+)-Gluconic acid gamma-lactone
  • D-delta-Gluconolactone
  • delta-D-Gluconolactone
  • delta-lactone,d-gluconicaci
  • d-Gluconic acid gamma-lactone
  • D-Gluconic acid-1,5-lactone
  • D-Gluconic delta-lactone
  • d-gluconicacid,sigma-lactone
  • d-gluconicdelta-lactone
  • d-Glucono-gamma-lactone
  • d-Threo-aldono-1,5-lactone
  • Fujiglucon
  • Glucarolactone
  • Gluconic acid, delta-lactone, D-
  • gluconicdelta-lactone
  • Glucono gamma-lactone
  • Glucopyrone
  • lactone,d-gluconicaci
  • 1,2,3,4,5-Pentahydroxycaproic acid δ-lactone
  • D-(+)-Dextronic acid δ-lactone
  • delta-Gluconolactone, coarse powder
  • Glucono-δ-lactone USP26 FCCIV
  • 1,5-d-gluconolactone
  • glucon-δ-lactone
  • Glucofuranose pentapropanoate
  • GLUCONOLACTONE, USP
  • D-GLUCONIC ACID LACTONE CELL CULTURE*TES TED
  • D-Glucono-D-Lactone FCC/USP, 99%
  • E575