ChemicalBook > CAS DataBase List > MERBARONE
MERBARONE
- Product Name
- MERBARONE
- CAS No.
- 97534-21-9
- Chemical Name
- MERBARONE
- Synonyms
- RLBN1001;RLBN-1001;MERBARONE;NSC-336628;Merbarone - CAS 97534-21-9 - Calbiochem;5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
- CBNumber
- CB4494665
- Molecular Formula
- C11H9N3O3S
- Formula Weight
- 263.27
- MOL File
- 97534-21-9.mol
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MERBARONE Property
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >5mg/mL
- form
- solid
- pka
- -2.16±0.20(Predicted)
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Safety
- WGK Germany
- 3
- RTECS
- UV7714625
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- M2070
- Product name
- Merbarone
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $161
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 445800
- Product name
- Merbarone
- Packaging
- 25mg
- Price
- $144
- Updated
- 2024/03/01
TRC
- Product number
- M800603
- Product name
- Merbarone
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
Usbiological
- Product number
- 454363
- Product name
- Merbarone
- Packaging
- 25mg
- Price
- $375
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0014735
- Product name
- Merbarone
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
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MERBARONE Chemical Properties,Usage,Production
Uses
Merbarone has been used to study its effect on the occurrence of DNA lesions.
General Description
A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 μM for purified mammalian topo II versus IC50 = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
Biochem/physiol Actions
Cell permeable: yes
MERBARONE Preparation Products And Raw materials
Raw materials
Preparation Products
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