ZEBULARINE

Product Name: ZEBULARINE
CAS No.: 3690-10-6
Chemical Name: ZEBULARINE
Synonyms: NSC 309132;4-Deoyuridine;4-Deoxyuridine;Zebularine Zebularine;Zebularine (NSC309132;NSC309132;4-DEOXYURIDINE;4-Deoyuridine,Zebularine;2-Pyrimidone-1-β-D-riboside;Uridine Impurity 23 (Zebularine);Pyrimidin-2-one -D-Ribofuranoside
CBNumber: CB4497499
Molecular Formula: C9H12N2O5
Formula Weight: 228.2
MOL File: 3690-10-6.mol

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ZEBULARINE Property

Melting point:: 160-162?C
Boiling point:: 499.0±55.0 °C(Predicted)
Density: 1.73±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 16 mg/mL, soluble
form: solid
pka: 13.48±0.70(Predicted)
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey: RPQZTTQVRYEKCR-WCTZXXKLSA-N

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Safety

WGK Germany: 3
RTECS: UW7539720
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 691400
Product name: Zebularine
Packaging: 10mg
Price: $216
Updated: 2024/03/01

Sigma-Aldrich

Product number: 691400
Product name: Zebularine
Packaging: 25mg
Price: $475
Updated: 2024/03/01

TCI Chemical

Product number: Z0022
Product name: Zebularine
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $193
Updated: 2024/03/01

TCI Chemical

Product number: Z0022
Product name: Zebularine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $571
Updated: 2024/03/01

Cayman Chemical

Product number: 10975
Product name: Zebularine
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

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ZEBULARINE Chemical Properties,Usage,Production

Description

Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine deaminase (Ki ~ 2 μM and; induces differentiation of mesenchymal stem cells into cardiomyocytes.

Chemical Properties

White Solid

Uses

It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

Definition

ChEBI: Zebularine is a member of pyrimidine ribonucleosides.

Biological Activity

Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC 50 = 120 μ M) and re-activates silenced genes in T24 bladder carcinoma cells. Also inhibits cytidine deaminase (K i ~ 2 μ M).

Biochem/physiol Actions

Zebularine is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

storage

Desiccate at RT

ZEBULARINE Preparation Products And Raw materials

Raw materials

Preparation Products

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ZEBULARINE Suppliers

Canada 1 China 88 India 3 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 4 United States 20 Global 119

Carbosynth

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Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Carbosynth Limited

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Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6581
Advantage: 61

Tocris Bioscience

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Fax: --
Email: customerservice@tocris.co.uk
Country: United Kingdom
ProdList: 5726
Advantage: 77

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

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View Lastest Price from ZEBULARINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: ZEBULARINE 3690-10-6
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-19

3690-10-6, ZEBULARINERelated Search:

5-METHYLCYTIDINE 6-[(3-chloropropyl)amino]-1,3-dimethyluracil URAPIDIL 5-METHYL- Uridine 5''-Monophosphate N,N-Dibutyl-1-butanamine Pseudouridine 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 2-Demethoxy-4-methoxy urapidil Quillaic acid (8α,9β,14β,23S,24R)-11β,23-Dihydroxy-24,25-epoxy-5α-dammar-13(17)-ene-3,16-dione Alisol B acetate SAPONIN, PRACT. FROM QUILLAJA SAPONARIA MOLINA Anisodine hydrobromide velutin Zearalenone Urapidil Impurity 20 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-β-D-ribofuranosyl]- 2,4(1H,3H)-Pyrimidinedione, 1-α-L-arabinofuranosyl- 2,4(1H,3H)-Pyrimidinedione, 1-β-L-arabinofuranosyl-

Zebularine - CAS 3690-10-6 - Calbiochem

NSC309132;4-DEOXYURIDINE

1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one

pyrimidin-2-one beta-ribofuranoside

1--D-Ribofuranosyl-2(1H)-pyrimidinone

4-Deoxyuridine

NSC 309132

Pyrimidin-2-one -D-Ribofuranoside

1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside

2(1H)-PyriMidinone, 1-b-D-ribofuranosyl-

4-Deoyuridine

1-b-D-ribofuranosyl-2-(1H)-pyriMidinone

anticancer drug, DNA Methylation inhibitor

2(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-

2-Pyrimidone-1-β-D-riboside

1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone

Pyrimidin-2-one beta-D-ribofuranoside

Zebularine Zebularine

Uridine Impurity 23 (Zebularine)

4-Deoyuridine, 1-beta-D-ribofuranosyl-2-(1H)-pyrimidinone

Zebularine (NSC309132

2-HYDROXY-PYRIMIDINE-1-B-D-RIBOSIDE

1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

1-beta-D-Ribofuranosyl -l ,2-dihydropyrimidin-2-one

NSC 309132,NSC-309132,DNMTs,Inhibitor,DNA MTases,Autophagy,Zebularine,DNA Methyltransferase,inhibit

4-Deoyuridine,Zebularine

2(1H)-Pyrimidinone, 1-beta-D-ribofuranosyl-

3690-10-6

Carbohydrates & Derivatives

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals