Sobuzoxane

Product Name: Sobuzoxane
CAS No.: 98631-95-9
Chemical Name: Sobuzoxane
Synonyms: e)(ester);Sobuzoxane;Perazoline;Sobuzoxane/MST 16;methylpropyl)ester;1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane;4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat;1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci;4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate);MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)
CBNumber: CB4498395
Molecular Formula: C22H34N4O10
Formula Weight: 514.53
MOL File: 98631-95-9.mol

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Sobuzoxane Property

Melting point:: 128-130°; mp 132-133° (Cai, 1989)
Boiling point:: 664.9±55.0 °C(Predicted)
Density: 1.272±0.06 g/cm3(Predicted)
solubility: DMSO: 19 mg/mL
form: solid
pka: 2.75±0.20(Predicted)

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Safety

WGK Germany: 2
RTECS: FG1582500
Toxicity: LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: S080860
Product name: Sobuzoxane
Packaging: 5mg
Price: $155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008426
Product name: SOBUZOXANE
Purity: 95.00%
Packaging: 5MG
Price: $719.1
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008426
Product name: SOBUZOXANE
Purity: 95.00%
Packaging: 25MG
Price: $1107.84
Updated: 2021/12/16

Crysdot

Product number: CD11000920
Product name: Sobuzoxane
Purity: 97%
Packaging: 100mg
Price: $840
Updated: 2021/12/16

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Sobuzoxane Chemical Properties,Usage,Production

Description

Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.

Originator

Zenyaku Kogyo (Japan)

Uses

Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.

Definition

ChEBI: Sobuzoxane is an organic molecular entity.

brand name

Perazolln

Sobuzoxane Preparation Products And Raw materials

Raw materials

Preparation Products

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Sobuzoxane Suppliers

China 5 Switzerland 1 United States 8 Global 14

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Riedel-de Haen AG

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Country: United States
ProdList: 6773
Advantage: 87

98631-95-9, SobuzoxaneRelated Search:

1,4-Dioxane Isobutylene oxide Propylene oxide ETHANE 1,1,1-Tris(hydroxymethyl)ethane 1-Methylpiperazine ETHYLIMINUM 4-(2-AMINO-ETHYL)-PIPERAZIN-2-ONE AMMONIUM CARBONATE TRIETHYLAMMONIUM FORMATE Piperazine-2,6-dione 1,1,4,7,10,10-HEXAMETHYLTRIETHYLENETETRAMINE 4-methylpiperazine-2,6-dione 1,1'-ethylenedipiperazine Sobuzoxane

1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane

1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci

4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat

e)(ester)

methylpropyl)ester

MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione)

4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate)

Perazoline

Sobuzoxane

[4-[2-[4-(2-METHYLPROPOXYCARBONYLOXYMETHYL)-3,5-DIOXOPIPERAZIN-1-YL]ETHYL]-2,6-DIOXOPIPERAZIN-1-YL]METHYL 2-METHYLPROPYL CARBONATE

Carbonic acid, C,C'-[1,2-ethanediylbis[(2,6-dioxo-4,1-piperazinediyl)methylene]] C,C'-bis(2-methylpropyl) ester

Sobuzoxane/MST 16

98631-95-9