ChemicalBook > CAS DataBase List > 5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-&

5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-&

Product Name
5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-&
CAS No.
51516-68-8
Chemical Name
5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-&
Synonyms
5-Amino-1-(3-chlorophenyl);5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-&;5-Amino-1-(3-chlorophenyl)pyrazole-4-carbonitrile;5-aMino-1-(3-chlorophenyl)-1H-pyrazple-4-carbonitrile;1H-Pyrazole-4-carbonitrile, 5-amino-1-(3-chlorophenyl)-;5-amino-1 - (3-chlorophenyl) - 1h-pyrazole-4-methylnitrile;5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile;5-Amino-1-(3-chlorophenyl)-1H<
CBNumber
CB4498931
Molecular Formula
C10H7ClN4
Formula Weight
218.64
MOL File
51516-68-8.mol
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5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-& Property

Melting point:
183-187 °C
Boiling point:
438.5±40.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
-1.09±0.10(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-36/39
WGK Germany 
3
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
A604058
Product name
5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile
Packaging
50mg
Price
$60
Updated
2021/12/16
TRC
Product number
A604058
Product name
5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile
Packaging
250mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
0886AQ
Product name
5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile
Packaging
1g
Price
$130
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0003261
Product name
5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
Purity
95.00%
Packaging
1G
Price
$485
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0003261
Product name
5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
Purity
95.00%
Packaging
2.5G
Price
$528
Updated
2021/12/16
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5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-& Chemical Properties,Usage,Production

Synthesis

2312-23-4

123-06-8

51516-68-8

Sodium hydride (60% mineral oil dispersion, 0.48 g, 12 mmol, 1.2 eq.) was slowly added to anhydrous ethanol (20 ml) at 0 °C. To the resulting ethanol solution of sodium ethanol was sequentially added 3-chlorophenylhydrazine hydrochloride (1.79 g, 10 mmol, 1.0 eq.) and ethoxymethylene malononitrile (1.22 g, 10 mmol, 1.0 eq.). The reaction mixture was heated to reflux with continuous stirring for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and precipitation was observed to be generated. Anhydrous ethanol (20 ml) was added to the reaction mixture for dilution, the precipitate was collected by filtration, washed with ether (2 x 100 ml) and dried under vacuum to afford the target compound 5-amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile as a yellow solid (1.56 g, 7.13 mmol, 72% yield).LCMS analysis: [M + H]+ = 219, retention time Rt = 1.17min, purity 100%.

References

[1] Patent: EP1746099, 2007, A1. Location in patent: Page/Page column 14
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 24, p. 7451 - 7454
[3] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 6, p. 1425 - 1428

5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-& Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-& Suppliers

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51516-68-8, 5-AMINO-1-(3-CHLOROPHENYL)-1H-PYRAZOLE-&Related Search:

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