ChemicalBook > CAS DataBase List > Ibandronic acid
Ibandronic acid
- Product Name
- Ibandronic acid
- CAS No.
- 114084-78-5
- Chemical Name
- Ibandronic acid
- Synonyms
- Ibandronic;BPH 24;Ibadronic Acid;Ibandronic acid;Ibandronate Acid;IBANDRONIC ACID-D3;Tirofiban Impurity 67;Ibandronic acid USP/EP/BP;Ibandronic Acid (Ibandronate);[1-Hydroxy-3-(MethylpentylaMino)propylidene]diphosphonic Acid
- CBNumber
- CB4500836
- Molecular Formula
- C9H23NO7P2
- Formula Weight
- 319.23
- MOL File
- 114084-78-5.mol
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Ibandronic acid Property
- Melting point:
- 113-115°C
- Boiling point:
- 587.8±60.0 °C(Predicted)
- Density
- 1.449±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- 1.60±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 114084-78-5(CAS DataBase Reference)
- EPA Substance Registry System
- Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis- (114084-78-5)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- I120000
- Product name
- IbandronicAcid
- Packaging
- 25mg
- Price
- $80
- Updated
- 2021/12/16
Usbiological
- Product number
- I0425
- Product name
- Ibandronic Acid
- Packaging
- 100mg
- Price
- $403
- Updated
- 2021/12/16
Usbiological
- Product number
- 014694
- Product name
- Ibandronic Acid-d3
- Packaging
- 2.5mg
- Price
- $425
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 100579
- Product name
- (1-Hydroxy-3-(methyl(pentyl)amino)propane-1,1-diyl)diphosphonic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $189
- Updated
- 2021/12/16
AK Scientific
- Product number
- G724
- Product name
- Ibandronicacid
- Packaging
- 5g
- Price
- $390
- Updated
- 2021/12/16
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Ibandronic acid Chemical Properties,Usage,Production
Description
This third generation biphosphonate was launched in Austria and Germany for the treatment of bone disorders such as hypercalcemia in malignancy and ostedysis, Paget's disease and osteoporosis. It does not effect bone mineralization, therefore, the potential risk of osteomalacia is prevented. This was a problem with first generation derivatives. While the exact mode of action is not understood, they are inhibitors of osteroclast mediated bone resorption. These compounds strongly interact with hydroxyapatite crystals and have a half-life in the skeleton of several years. Despite this observation ibandronate was well tolerated and safe.
Chemical Properties
White Solid
Originator
Boehringer Mannheim (Germany)
Uses
Labelled Ibandronic Acid (I120000). A bisphosphonate antiresorptive agent. Bone resorption inhibitor.
Uses
A bisphosphonate antiresorptive agent. Bone resorption inhibitor.
Uses
A biphosphonate bone resorption inhibitor.
Uses
A labeled biphosphonate bone resorption inhibitor.
brand name
Bondronat
Clinical Use
Bisphosphonate:
Reduction of bone damage in bone metastases in
breast cancer
Hypercalcaemia of malignancy
Postmenopausal osteoporosis
Metabolism
After initial systemic exposure, ibandronic acid rapidly binds to bone or is excreted into urine. There is no evidence that ibandronic acid is metabolised in animals or humans. The absorbed fraction of ibandronic acid is removed from the circulation via bone absorption (estimated to be 40-50% in postmenopausal women) and the remainder is eliminated unchanged by the kidney. The unabsorbed fraction of ibandronic acid is eliminated unchanged in the faeces. Renal clearance accounts for 50-60% of total clearance and is related to creatinine clearance. The difference between the apparent total and renal clearances is considered to reflect the uptake by bone.
Ibandronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ibandronic acid manufacturers
Sinoway Industrial co., ltd.
- Product
- Ibandronic Acid 114084-78-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20TONS
- Release date
- 2024-09-03
Hebei Zhanyao Biotechnology Co. Ltd
- Product
- Ibandronic acid 114084-78-5
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-02
Dideu Industries Group Limited
- Product
- Ibandronic acid 114084-78-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-28
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