ChemicalBook > CAS DataBase List > Ibandronic acid

Ibandronic acid

Product Name
Ibandronic acid
CAS No.
114084-78-5
Chemical Name
Ibandronic acid
Synonyms
Ibandronic;BPH 24;Ibadronic Acid;Ibandronic acid;Ibandronate Acid;IBANDRONIC ACID-D3;Tirofiban Impurity 67;Ibandronic acid USP/EP/BP;[1-Hydroxy-3-(MethylpentylaMino)propylidene]diphosphonic Acid;1-Hydroxy-3-(methylpentylamino)propylidene bisphosphonic acid
CBNumber
CB4500836
Molecular Formula
C9H23NO7P2
Formula Weight
319.23
MOL File
114084-78-5.mol
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Ibandronic acid Property

Melting point:
113-115°C
Boiling point:
587.8±60.0 °C(Predicted)
Density 
1.449±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly)
pka
1.60±0.10(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
CAS DataBase Reference
114084-78-5(CAS DataBase Reference)
EPA Substance Registry System
Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis- (114084-78-5)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
I120000
Product name
IbandronicAcid
Packaging
25mg
Price
$80
Updated
2021/12/16
Usbiological
Product number
I0425
Product name
Ibandronic Acid
Packaging
100mg
Price
$403
Updated
2021/12/16
Usbiological
Product number
014694
Product name
Ibandronic Acid-d3
Packaging
2.5mg
Price
$425
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D11082
Product name
IbandronicAcid-d3
Packaging
1mg
Price
$875
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D11082
Product name
IbandronicAcid-d3
Packaging
10mg
Price
$2000
Updated
2021/12/16
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Ibandronic acid Chemical Properties,Usage,Production

Description

This third generation biphosphonate was launched in Austria and Germany for the treatment of bone disorders such as hypercalcemia in malignancy and ostedysis, Paget's disease and osteoporosis. It does not effect bone mineralization, therefore, the potential risk of osteomalacia is prevented. This was a problem with first generation derivatives. While the exact mode of action is not understood, they are inhibitors of osteroclast mediated bone resorption. These compounds strongly interact with hydroxyapatite crystals and have a half-life in the skeleton of several years. Despite this observation ibandronate was well tolerated and safe.

Chemical Properties

White Solid

Originator

Boehringer Mannheim (Germany)

Uses

Labelled Ibandronic Acid (I120000). A bisphosphonate antiresorptive agent. Bone resorption inhibitor.

Uses

A bisphosphonate antiresorptive agent. Bone resorption inhibitor.

Uses

A biphosphonate bone resorption inhibitor.

Uses

A labeled biphosphonate bone resorption inhibitor.

brand name

Bondronat

Clinical Use

Bisphosphonate:

Reduction of bone damage in bone metastases in breast cancer

Hypercalcaemia of malignancy

Postmenopausal osteoporosis

Metabolism

After initial systemic exposure, ibandronic acid rapidly binds to bone or is excreted into urine. There is no evidence that ibandronic acid is metabolised in animals or humans. The absorbed fraction of ibandronic acid is removed from the circulation via bone absorption (estimated to be 40-50% in postmenopausal women) and the remainder is eliminated unchanged by the kidney. The unabsorbed fraction of ibandronic acid is eliminated unchanged in the faeces. Renal clearance accounts for 50-60% of total clearance and is related to creatinine clearance. The difference between the apparent total and renal clearances is considered to reflect the uptake by bone.

Ibandronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ibandronic acid manufacturers

Hebei Duling International Trade Co. LTD
Product
Ibandronic acid 114084-78-5
Price
US $25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-03-21
Hebei Zhanyao Biotechnology Co. Ltd
Product
Ibandronic acid 114084-78-5
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-02
Dideu Industries Group Limited
Product
Ibandronic acid 114084-78-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28

114084-78-5, Ibandronic acidRelated Search:

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  • {1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphnic Acid
  • [1-Hydroxy-3-(methyl-d3-pentylamino)propylidene]bisphosphnic Acid
  • Ibandronic
  • IBANDRONIC ACID-D3
  • 1-Hydroxy-3-(methylpentylamino)propylidene bisphosphonic acid
  • Ibandronic acid
  • P,P'-[1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic Acid
  • Ibadronic Acid
  • Ibandronate Acid
  • [1-Hydroxy-3-(MethylpentylaMino)propylidene]diphosphonic Acid
  • BPH 24
  • (1-Hydroxy-3-(Methyl(pentyl)aMino)propane-1,1-diyl)diphosphonic acid
  • Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-
  • Ibandronic acid USP/EP/BP
  • IbandronateQ: What is Ibandronate Q: What is the CAS Number of Ibandronate Q: What is the storage condition of Ibandronate Q: What are the applications of Ibandronate
  • Tirofiban Impurity 67
  • 114084-78-5
  • 14084-78-5
  • C9H20D3NO7P2
  • C9H23NO7P2
  • C9H25O7NP2
  • C9H20NO7P2D3
  • Phosphorylating and Phosphitylating Agents
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Isotope Labeled Compounds
  • anti-osteoporosis