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SECO RAPAMYCIN SODIUM SALT

Product Name
SECO RAPAMYCIN SODIUM SALT
CAS No.
148554-65-8
Chemical Name
SECO RAPAMYCIN SODIUM SALT
Synonyms
Secosirolimus;Secorapamycin Na salt;SECORAPAMYCIN A MONOSODIUM;SECO RAPAMYCIN SODIUM SALT;seco Rapamycin Sodium Salt, >85% By HPLC;(19E/Z)-seco Rapamycin Sodium Salt (>80%);(19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC);(19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)
CBNumber
CB4501000
Molecular Formula
C51H80NNaO13
Formula Weight
938.18
MOL File
148554-65-8.mol
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SECO RAPAMYCIN SODIUM SALT Property

Melting point:
120-122°C
storage temp. 
Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Yellow to Yellow
Stability:
Light Sensitive
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16158
Product name
Seco Rapamycin (sodium salt)
Purity
≥85%
Packaging
1mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
16158
Product name
Seco Rapamycin (sodium salt)
Purity
≥85%
Packaging
10mg
Price
$701
Updated
2024/03/01
Cayman Chemical
Product number
16158
Product name
Seco Rapamycin (sodium salt)
Purity
≥85%
Packaging
500μg
Price
$65
Updated
2021/12/16
Cayman Chemical
Product number
16158
Product name
Seco Rapamycin (sodium salt)
Purity
≥85%
Packaging
5mg
Price
$468
Updated
2024/03/01
TRC
Product number
R124010
Product name
(19E/Z)-secoRapamycinSodiumSalt(~80%byHPLC)
Packaging
10mg
Price
$205
Updated
2021/12/16
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SECO RAPAMYCIN SODIUM SALT Chemical Properties,Usage,Production

Description

Rapamycin is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.

Chemical Properties

Yellow Solid

Uses

A metabolite of Sirolimus

Uses

A decomposition product of Rapamycin (R124000).

References

[1] C. P. WANG. High Performance Liquid Chromatographic Isolation, Spectroscopic Characterization, and Immunosuppressive Activities of Two Rapamycin Degradation Products[J]. Journal of Liquid Chromatography & Related Technologies, 1994, 17 1: 3383-3392. DOI: 10.1080/10826079408013519
[2] PAINE M, LEUNG L, LIM H, et al. Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion.[J]. The Journal of Pharmacology and Experimental Therapeutics, 2002, 11 1: 0. DOI: 10.1124/jpet.301.1.174
[3] MARY F PAINE  Paul B W  Louis Y Leung. New insights into drug absorption: studies with sirolimus.[J]. Therapeutic Drug Monitoring, 2004, 26 5: 463-467. DOI: 10.1097/00007691-200410000-00001
[4] PAWEL A OSMULSKI M G. Rapamycin allosterically inhibits the proteasome.[J]. Molecular Pharmacology, 2013, 84 1: 104-113. DOI: 10.1124/mol.112.083873

SECO RAPAMYCIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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148554-65-8, SECO RAPAMYCIN SODIUM SALTRelated Search:

Rapamycin N-DECANOYLSARCOSINE SODIUM SALT SECO RAPAMYCIN SODIUM SALT

  • SECORAPAMYCIN A MONOSODIUM
  • seco Rapamycin Sodium Salt, >85% By HPLC
  • SECO RAPAMYCIN SODIUM SALT
  • (19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)
  • (19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC)
  • Secorapamycin Na salt
  • Secosirolimus
  • (19E/Z)-seco Rapamycin Sodium Salt (>80%)
  • 148554-65-8
  • C51H78NNaO13
  • Metabolites & Impurities
  • Various Metabolites and Impurities
  • Chiral Reagents
  • Heterocycles
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals