OSI-420
- Product Name
- OSI-420
- CAS No.
- 183321-86-0
- Chemical Name
- OSI-420
- Synonyms
- OSI-420;CP 373420;Erlotinib-10;OSI-420 impurity;β-Amyloid (1-42);OSI-420 (free base);ROSCOVITINE(CVC202);Erlotinib iMpurity H;Erlotinib impurity J;Erlotinib impurity N
- CBNumber
- CB4501590
- Molecular Formula
- C21H21N3O4
- Formula Weight
- 379.41
- MOL File
- 183321-86-0.mol
OSI-420 Property
- Melting point:
- 140-142°C
- Density
- 1.30
- storage temp.
- -20°C Freezer
- solubility
- insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23394
- Product name
- Desmethyl Erlotinib
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 23394
- Product name
- Desmethyl Erlotinib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- 23394
- Product name
- Desmethyl Erlotinib
- Packaging
- 10mg
- Price
- $370
- Updated
- 2024/03/01
- Product number
- O702250
- Product name
- OSI-420,FreeBase(DesmethylErlotinib)
- Packaging
- 1mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- FO26597
- Product name
- Desmethyl erlotinib
- Packaging
- 5mg
- Price
- $294
- Updated
- 2021/12/16
OSI-420 Chemical Properties,Usage,Production
Description
Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.
Chemical Properties
Off-White Solid
Uses
A metabolite of Erlotinib (E625000), an anti cancer agent.
Uses
OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
References
[1] zhang w1, siu ll, moore mj, chen ex.simultaneous determination of osi-774 and its major metabolite osi-420 in human plasma by using hplc with uv detection. j chromatogr b analyt technol biomed life sci. 2005 jan 5;814(1):143-7.
[2] bonomi p. erlotinib: a new therapeutic approach for non-small cell lung cancer.expert opin investig drugs. 2003 aug;12(8):1395-401.