ChemicalBook > CAS DataBase List > OSI-420

OSI-420

Product Name
OSI-420
CAS No.
183321-86-0
Chemical Name
OSI-420
Synonyms
OSI-420;CP 373420;Erlotinib-10;OSI-420 impurity;β-Amyloid (1-42);OSI-420 (free base);ROSCOVITINE(CVC202);Erlotinib iMpurity H;Erlotinib impurity J;Erlotinib impurity N
CBNumber
CB4501590
Molecular Formula
C21H21N3O4
Formula Weight
379.41
MOL File
183321-86-0.mol
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OSI-420 Property

Melting point:
140-142°C
Density 
1.30
storage temp. 
-20°C Freezer
solubility 
insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form 
A crystalline solid
color 
White to off-white
InChI
InChI=1S/C21H21N3O4/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24)
InChIKey
KOQIAZNBAWFSQM-UHFFFAOYSA-N
SMILES
C(O)COC1C(OCCOC)=CC2C(C=1)=C(NC1=CC=CC(C#C)=C1)N=CN=2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23394
Product name
Desmethyl Erlotinib
Purity
≥98%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
23394
Product name
Desmethyl Erlotinib
Purity
≥98%
Packaging
5mg
Price
$201
Updated
2024/03/01
Cayman Chemical
Product number
23394
Product name
Desmethyl Erlotinib
Packaging
10mg
Price
$370
Updated
2024/03/01
TRC
Product number
O702250
Product name
OSI-420,FreeBase(DesmethylErlotinib)
Packaging
1mg
Price
$275
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO26597
Product name
Desmethyl erlotinib
Packaging
5mg
Price
$294
Updated
2021/12/16
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OSI-420 Chemical Properties,Usage,Production

Description

Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.

Chemical Properties

Off-White Solid

Uses

A metabolite of Erlotinib (E625000), an anti cancer agent.

Uses

OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.

References

[1] zhang w1, siu ll, moore mj, chen ex.simultaneous determination of osi-774 and its major metabolite osi-420 in human plasma by using hplc with uv detection. j chromatogr b analyt technol biomed life sci. 2005 jan 5;814(1):143-7.
[2] bonomi p. erlotinib: a new therapeutic approach for non-small cell lung cancer.expert opin investig drugs. 2003 aug;12(8):1395-401.

OSI-420 Preparation Products And Raw materials

Raw materials

Preparation Products

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OSI-420 Suppliers

Canada 1 China 112 India 4 United Kingdom 1 United States 16 Global 134
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183321-86-0, OSI-420Related Search:

OSI-420-d4, Free Base (Desmethyl Erlotinib-d4) Erlotinib IMpurity C Erlotinib Erlotinib Impurity 35 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Erlotinib Impurity 67 Olmutinib XL-647 Genistein AZD 3759 AG 1478 HYDROCHLORIDE Anlotinib EGF816 Tucatinib Neratinib Poziotinib (HM781-36B) CO-1686 Dacomitinib (PF299804)

  • Erlotinib-10
  • Erlotinib 6-O-Desmethyl Metabolite
  • Erlotinib Hydrochloride iMpurity 9
  • 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)
  • OSI-420 impurity
  • Erlotinib O-Desmethyl Metabolite Isomer
  • 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quizolin-6-yl)oxy)ethan-1-ol
  • 6-O-Desmethyl Erlotinib
  • CP 373420
  • OSI-420 (free base)
  • Erlotinib O-DesMethyl Metabolite
  • Erlotinib iMpurity H
  • Desmethyl Erlotinib (CP-473420, OSI-420)
  • 6-O-Desmethyl Erlotinib 1
  • 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol
  • 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
  • Erlotinib impurity J
  • Erlotinib impurity N
  • Erlotinib O-Desmethyl Metabolite Isomer (M14)
  • Erlotinib impurity 16/Desmethyl Erlotinib/2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol
  • OSI-420
  • ROSCOVITINE(CVC202)
  • Desmethyl Erlotinib (CP-473420, OSI-774)
  • Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-
  • Azilsartan medoxomil impurity247
  • Erlotinib impurities405
  • Erlotinib O-Desmethyl Metabolite (M14)
  • β-Amyloid (1-42)
  • Erlotinib Impurity 167
  • Desmethyl Erlotinib, 10 mM in DMSO
  • D4-O-Desmethyl erlotinib
  • 183321-86-0
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Heterocycles