OSI-420

Product Name: OSI-420
CAS No.: 183321-86-0
Chemical Name: OSI-420
Synonyms: OSI-420;CP 373420;Erlotinib-10;OSI-420 impurity;β-Amyloid (1-42);OSI-420 (free base);ROSCOVITINE(CVC202);Erlotinib iMpurity H;Erlotinib impurity J;Erlotinib impurity N
CBNumber: CB4501590
Molecular Formula: C21H21N3O4
Formula Weight: 379.41
MOL File: 183321-86-0.mol

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OSI-420 Property

Melting point:: 140-142°C
Density: 1.30
storage temp.: -20°C Freezer
solubility: insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23394
Product name: Desmethyl Erlotinib
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 23394
Product name: Desmethyl Erlotinib
Purity: ≥98%
Packaging: 5mg
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 23394
Product name: Desmethyl Erlotinib
Packaging: 10mg
Price: $370
Updated: 2024/03/01

TRC

Product number: O702250
Product name: OSI-420,FreeBase(DesmethylErlotinib)
Packaging: 1mg
Price: $275
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO26597
Product name: Desmethyl erlotinib
Packaging: 5mg
Price: $294
Updated: 2021/12/16

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OSI-420 Chemical Properties,Usage,Production

Description

Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC₅₀ = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED₅₀ value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC₅₀ = 4.6 μM) and JAK2 mutant JAK2^V617F positive hematopoietic progenitor cells (IC₅₀ = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.

Chemical Properties

Off-White Solid

Uses

A metabolite of Erlotinib (E625000), an anti cancer agent.

Uses

OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.

References

[1] zhang w1, siu ll, moore mj, chen ex.simultaneous determination of osi-774 and its major metabolite osi-420 in human plasma by using hplc with uv detection. j chromatogr b analyt technol biomed life sci. 2005 jan 5;814(1):143-7.
[2] bonomi p. erlotinib: a new therapeutic approach for non-small cell lung cancer.expert opin investig drugs. 2003 aug;12(8):1395-401.

OSI-420 Preparation Products And Raw materials

Raw materials

Preparation Products

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OSI-420 Suppliers

Canada 1 China 94 India 4 United Kingdom 1 United States 16 Global 116

Hebei Mingji Chemical Technology Co., Ltd

Tel: 13731109507
Email: 1581841507@qq.com
Country: China
ProdList: 491
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Beijing Comparison Pharmaceutical Technology Co., Ltd

Tel: 010-010-52878169 15801002657
Email: sales@bjcomparison.com
Country: China
ProdList: 4953
Advantage: 58

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

Chengdu Aofan Pharmtech Co.,Ltd

Tel: 15281070185
Email: 2865097598@qq.com
Country: China
ProdList: 97
Advantage: 55

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

183321-86-0, OSI-420Related Search:

OSI-420-d4, Free Base (Desmethyl Erlotinib-d4) Erlotinib IMpurity C Erlotinib Erlotinib Impurity 35 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Erlotinib Impurity 67 Olmutinib XL-647 Genistein AZD 3759 AG 1478 HYDROCHLORIDE Anlotinib EGF816 Tucatinib Neratinib Poziotinib (HM781-36B) CO-1686 Dacomitinib (PF299804)

Erlotinib-10

Erlotinib 6-O-Desmethyl Metabolite

Erlotinib Hydrochloride iMpurity 9

2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)

OSI-420 impurity

Erlotinib O-Desmethyl Metabolite Isomer

2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quizolin-6-yl)oxy)ethan-1-ol

6-O-Desmethyl Erlotinib

CP 373420

OSI-420 (free base)

Erlotinib O-DesMethyl Metabolite

Erlotinib iMpurity H

Desmethyl Erlotinib (CP-473420, OSI-420)

6-O-Desmethyl Erlotinib 1

2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol

2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol

Erlotinib impurity J

Erlotinib impurity N

Erlotinib O-Desmethyl Metabolite Isomer (M14)

Erlotinib impurity 16/Desmethyl Erlotinib/2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol

OSI-420

ROSCOVITINE(CVC202)

Desmethyl Erlotinib (CP-473420, OSI-774)

Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-

Azilsartan medoxomil impurity247

Erlotinib impurities405

Erlotinib O-Desmethyl Metabolite (M14)

β-Amyloid (1-42)

Erlotinib Impurity 167

183321-86-0

Inhibitors

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Heterocycles