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CKI-7

Product Name
CKI-7
CAS No.
120615-25-0
Chemical Name
CKI-7
Synonyms
CKI-7 free base;CKI 7 free base,CKI7 free base;N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide;N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-;8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride
CBNumber
CB4503226
Molecular Formula
C11H12ClN3O2S
Formula Weight
285.75
MOL File
120615-25-0.mol
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CKI-7 Property

Melting point:
188-190°C
Boiling point:
499.7±55.0 °C(Predicted)
Density 
1.432±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: 9 mg/mL
pka
7.80±0.50(Predicted)
form 
solid
color 
white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

TRC
Product number
A608850
Product name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Packaging
10mg
Price
$150
Updated
2021/12/16
TRC
Product number
A608850
Product name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Packaging
50mg
Price
$625
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17736
Product name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Packaging
25mg
Price
$675
Updated
2021/12/16
Apolloscientific
Product number
OR0885T
Product name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide
Packaging
25mg
Price
$777
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
6544
Product name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Packaging
10mg
Price
$860
Updated
2021/12/16
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CKI-7 Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Solid

Uses

CKI-7 is found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases.

Definition

ChEBI: A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.

in vivo

In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death[2].

IC 50

CK1: 6 μM (IC50); CK1: 8.5 μM (Ki); Cdc7; SGK; MSK1

CKI-7 Preparation Products And Raw materials

Raw materials

Preparation Products

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CKI-7 Suppliers

Canada 1 China 20 Germany 1 South Korea 1 Switzerland 1 United Kingdom 2 United States 8 Global 34
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5002
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Yeasen Biotechnology (Shanghai) Co Ltd
Tel
400-6111-883 13121892008
Email
marketing@yeasen.com
Country
China
ProdList
6173
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
DAYANG CHEM (HANGZHOU) CO.,LTD
Tel
+86-88938639 +86-17705817739
Email
info@dycnchem.com
Country
China
ProdList
53899
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
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58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com
Country
China
ProdList
6187
Advantage
67

120615-25-0, CKI-7Related Search:

CKI-7 5-CHLOROISOQUINOLINE

  • 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride
  • 8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7
  • N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide
  • N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide
  • CKI-7 free base
  • 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-
  • CKI 7 free base,CKI7 free base
  • 120615-25-0
  • C11H12ClN3O2S2HCl
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • All Inhibitors