CKI-7
- Product Name
- CKI-7
- CAS No.
- 120615-25-0
- Chemical Name
- CKI-7
- Synonyms
- CKI-7 free base;CKI 7 free base,CKI7 free base;N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide;N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-;8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride
- CBNumber
- CB4503226
- Molecular Formula
- C11H12ClN3O2S
- Formula Weight
- 285.75
- MOL File
- 120615-25-0.mol
CKI-7 Property
- Melting point:
- 188-190°C
- Boiling point:
- 499.7±55.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- H2O: 9 mg/mL
- pka
- 7.80±0.50(Predicted)
- form
- solid
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
N-Bromosuccinimide Price
- Product number
- A608850
- Product name
- N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- A608850
- Product name
- N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
- Packaging
- 50mg
- Price
- $625
- Updated
- 2021/12/16
- Product number
- FA17736
- Product name
- N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
- Packaging
- 25mg
- Price
- $675
- Updated
- 2021/12/16
- Product number
- OR0885T
- Product name
- N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide
- Packaging
- 25mg
- Price
- $777
- Updated
- 2021/12/16
- Product number
- 6544
- Product name
- N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
- Packaging
- 10mg
- Price
- $860
- Updated
- 2021/12/16
CKI-7 Chemical Properties,Usage,Production
Chemical Properties
Off-White Crystalline Solid
Uses
CKI-7 is found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases.
Definition
ChEBI: A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.
in vivo
In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death[2].
IC 50
CK1: 6 μM (IC50); CK1: 8.5 μM (Ki); Cdc7; SGK; MSK1
CKI-7 Preparation Products And Raw materials
Raw materials
Preparation Products
CKI-7 Suppliers
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70