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CKI-7

Product Name
CKI-7
CAS No.
120615-25-0
Chemical Name
CKI-7
Synonyms
CKI-7 free base;CKI 7 free base,CKI7 free base;N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide;N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-;8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7;8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride
CBNumber
CB4503226
Molecular Formula
C11H12ClN3O2S
Formula Weight
285.75
MOL File
120615-25-0.mol
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CKI-7 Property

Melting point:
188-190°C
Boiling point:
499.7±55.0 °C(Predicted)
Density 
1.432±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: 9 mg/mL
pka
7.80±0.50(Predicted)
form 
solid
color 
white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

TRC
Product number
A608850
Product name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Packaging
10mg
Price
$150
Updated
2021/12/16
TRC
Product number
A608850
Product name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Packaging
50mg
Price
$625
Updated
2021/12/16
ChemScene
Product number
CS-0109499
Product name
CKI-7(freebase)
Purity
99.31%
Packaging
5mg
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17736
Product name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Packaging
2mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0109499
Product name
CKI-7(freebase)
Purity
99.31%
Packaging
10mg
Price
$150
Updated
2021/12/16
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CKI-7 Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Solid

Uses

CKI-7 is found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases.

Definition

ChEBI: A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.

in vivo

In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death[2].

IC 50

CK1: 6 μM (IC50); CK1: 8.5 μM (Ki); Cdc7; SGK; MSK1

CKI-7 Preparation Products And Raw materials

Raw materials

Preparation Products

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CKI-7 Suppliers

Canada 1 China 20 Germany 1 South Korea 1 Switzerland 1 United Kingdom 2 United States 8 Global 34
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94644
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
Country
Germany
ProdList
4705
Advantage
70
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58

120615-25-0, CKI-7Related Search:

CKI-7 5-CHLOROISOQUINOLINE

  • 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro- Dihydrochloride
  • 8-[N-(2-Aminoethyl)sulphamoyl]-5-chloroisoquinoline, CKI-7
  • N-(2-AMinoethyl)-5-chloro-isoquinolin-8-sulphonaMide
  • N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide
  • CKI-7 free base
  • 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-
  • CKI 7 free base,CKI7 free base
  • 120615-25-0
  • C11H12ClN3O2S2HCl
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • All Inhibitors