2-CHLORO-3-HYDROXYBENZALDEHYDE 97
- Product Name
- 2-CHLORO-3-HYDROXYBENZALDEHYDE 97
- CAS No.
- 56962-10-8
- Chemical Name
- 2-CHLORO-3-HYDROXYBENZALDEHYDE 97
- Synonyms
- 2-chloro-3-hydroxy-;Benzaldehyde, 2-chloro-3-hydroxy-;2-CHLORO-3-HYDROXYBENZALDEHYDE 97;2-Chloro-3-hydroxybenzaldehyde 97%
- CBNumber
- CB4505396
- Molecular Formula
- C7H5ClO2
- Formula Weight
- 156.57
- MOL File
- 56962-10-8.mol
2-CHLORO-3-HYDROXYBENZALDEHYDE 97 Property
- Melting point:
- 139-143 °C (lit.)
- Boiling point:
- 245.0±20.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- 7.77±0.10(Predicted)
- color
- Off-white to faint orange
- InChIKey
- SEEAPLJEIJXFFU-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 22-37/38-41-50
- Safety Statements
- 26-36-60-61
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 2
- HazardClass
- 9
- PackingGroup
- Ⅲ
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 647365
- Product name
- 2-Chloro-3-hydroxybenzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $57
- Updated
- 2023/01/07
- Product number
- 647365
- Product name
- 2-Chloro-3-hydroxybenzaldehyde
- Purity
- 97%
- Packaging
- 10g
- Price
- $248
- Updated
- 2023/01/07
- Product number
- C459100
- Product name
- 2-chloro-3-hydroxy-Benzaldehyde
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 228235
- Product name
- 2-Chloro-3-hydroxybenzaldehyde
- Purity
- 95%
- Packaging
- 250mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 8348AB
- Product name
- 2-Chloro-3-hydroxybenzaldehyde
- Packaging
- 5g
- Price
- $141
- Updated
- 2021/12/16
2-CHLORO-3-HYDROXYBENZALDEHYDE 97 Chemical Properties,Usage,Production
Uses
2-chloro-3-hydroxy-Benzaldehyde is a versatile building block used in the preparation of positional isomers of NOSH-aspirin a dual nitric oxide and hydrogen sulfide releasing hybrid pharmaceutical.
Synthesis
100-83-4
56962-10-8
Under stirring conditions, tBuOCl (20 mL, 176 mmol) was slowly added dropwise to a suspension of 3-hydroxybenzaldehyde (20.12 g, 160 mmol) in HOAc (40 mL). The reaction solution gradually changed to a clarified solution with significant exothermic phenomenon. The reaction mixture was cooled and stirred continuously for 16 h, during which a white precipitate was generated. The solid product was collected by filtration, washed with deionized water and dried to afford 2-chloro-3-hydroxybenzaldehyde (13.77 g, 55% yield), which was analyzed by GCMS (EI) showing m/z 156,158 (M+). Subsequently, 2-chloro-3-hydroxybenzaldehyde (4.55 g, 29 mmol) was dissolved in DMF (30 mL), and K2CO3 (4.8 g, 34.9 mmol) and MeI (2.7 mL, 43.6 mmol) were added sequentially, and the reaction was stirred for 16 h at room temperature. After the reaction was completed, the solvent was removed by distillation under reduced pressure, and the residue was dissolved with ethyl acetate, washed with water and saturated saline in turn, dried over anhydrous Na2SO4 and concentrated. Purification was carried out by silica gel column chromatography with ethyl acetate/hexane (1:5) as eluent to obtain 2-chloro-3-methoxybenzaldehyde 3a (4.68 g, 94% yield) as a colorless oil, which was solidified after standing.GCMS (EI) analysis showed m/z 170,172 (M+).
References
[1] ACS Catalysis, 2018, vol. 8, # 5, p. 4033 - 4043
[2] Australian Journal of Chemistry, 2005, vol. 58, # 8, p. 565 - 571
[3] Patent: WO2005/7164, 2005, A1. Location in patent: Page 30-31
[4] Patent: WO2005/7165, 2005, A1. Location in patent: Page 46
[5] Patent: WO2005/7633, 2005, A1. Location in patent: Page 33
2-CHLORO-3-HYDROXYBENZALDEHYDE 97 Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-3-HYDROXYBENZALDEHYDE 97 Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0535-6385396
- Fax
- +86 (535) 638-9971
- info@carbottpharm.com
- Country
- China
- ProdList
- 957
- Advantage
- 56
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
View Lastest Price from 2-CHLORO-3-HYDROXYBENZALDEHYDE 97 manufacturers
- Product
- 2-CHLORO-3-HYDROXYBENZALDEHYDE 97 56962-10-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-05-24