ChemicalBook > CAS DataBase List > 1,4-dihydroxy-2naphthoic acid methyl ester

1,4-dihydroxy-2naphthoic acid methyl ester

Product Name
1,4-dihydroxy-2naphthoic acid methyl ester
CAS No.
77060-74-3
Chemical Name
1,4-dihydroxy-2naphthoic acid methyl ester
Synonyms
Methyl 1,4-dihydroxy-2-phthoate;METHYL-1,4-DIHYDROXY-2-NAPHTHOATE;1,4-Dihydroxy-2-naphthoic acid methylester;1,4-Dihydroxy-2-naphthalenecarboxylic acid methyl ester;2-Naphthalenecarboxylic acid, 1,4-dihydroxy-, methyl ester
CBNumber
CB4511614
Molecular Formula
C12H10O4
Formula Weight
218.21
MOL File
77060-74-3.mol
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1,4-dihydroxy-2naphthoic acid methyl ester Property

Melting point:
192-193 ºC
Boiling point:
432.9±25.0 °C(Predicted)
Density 
1.378
storage temp. 
2-8°C
pka
8.77±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0987545
Product name
1,4-DIHYDROXY-2-NAPHTHALENECARBOXYLIC ACID METHYL ESTER
Purity
95.00%
Packaging
5MG
Price
$504.09
Updated
2021/12/16
Chemenu
Product number
CM128377
Product name
methyl1,4-dihydroxy-2-naphthoate
Purity
95%
Packaging
1g
Price
$333
Updated
2021/12/16
Crysdot
Product number
CD41000402
Product name
Methyl1,4-dihydroxy-2-naphthoate
Purity
95+%
Packaging
1g
Price
$356
Updated
2021/12/16
Alichem
Product number
77060743
Product name
Methyl1,4-dihydroxy-2-naphthoate
Packaging
5g
Price
$391.02
Updated
2021/12/16
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1,4-dihydroxy-2naphthoic acid methyl ester Chemical Properties,Usage,Production

Uses

1,4-dihydroxy-2naphthoic acid methyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


To a stirred solution of LiOt-Bu (3.20 mmol) in THF (10 mL) at -78 ??C(CHCl3-liq N2 bath) under an inert atmosphere was added a solutionof isocyanophthalide (1.0 mmol) in THF (5 mL). The resulting yellowish solution was stirred at -78 ??C for 25 min, after which a solution of a Michael acceptor (1.0-1.5 equiv unless otherwise stated) in THF (5mL) was added. The cooling bath was removed after ca. 1 h at -78 ??C and the mixture was brought to r.t. over a period of 1 h and stirred fora further 2-6 h. The reaction was then quenched with 10% aq NH4Cl(15 mL) and the resulting solution was concentrated. The residue was diluted with EtOAc (50 mL) and the layers were separated. The aqueous layer was extracted with EtOAc (3 ?á 25 mL). The combined extracts were washed with H2O (15 mL) and brine (15 mL), dried (anhydNa2SO4), and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel) or by recrystallizationto obtain the pure product.

1,4-dihydroxy-2naphthoic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,4-dihydroxy-2naphthoic acid methyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 1,4-dihydroxy-2-naphthoate 77060-74-3
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 1,4-dihydroxy-2- naphthoate 77060-74-3
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-15
Career Henan Chemical Co
Product
Methyl 1,4-dihydroxy-2-naphthoate 77060-74-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

77060-74-3, 1,4-dihydroxy-2naphthoic acid methyl esterRelated Search:

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  • Methyl 1,4-dihydroxy-2-phthoate
  • METHYL-1,4-DIHYDROXY-2-NAPHTHOATE
  • 1,4-Dihydroxy-2-naphthoic acid methylester
  • 1,4-Dihydroxy-2-naphthalenecarboxylic acid methyl ester
  • 2-Naphthalenecarboxylic acid, 1,4-dihydroxy-, methyl ester
  • 77060-74-3