1,4-dihydroxy-2naphthoic acid methyl ester
- Product Name
- 1,4-dihydroxy-2naphthoic acid methyl ester
- CAS No.
- 77060-74-3
- Chemical Name
- 1,4-dihydroxy-2naphthoic acid methyl ester
- Synonyms
- Methyl 1,4-dihydroxy-2-phthoate;METHYL-1,4-DIHYDROXY-2-NAPHTHOATE;1,4-Dihydroxy-2-naphthoic acid methylester;1,4-Dihydroxy-2-naphthalenecarboxylic acid methyl ester;2-Naphthalenecarboxylic acid, 1,4-dihydroxy-, methyl ester
- CBNumber
- CB4511614
- Molecular Formula
- C12H10O4
- Formula Weight
- 218.21
- MOL File
- 77060-74-3.mol
1,4-dihydroxy-2naphthoic acid methyl ester Property
- Melting point:
- 192-193 ºC
- Boiling point:
- 432.9±25.0 °C(Predicted)
- Density
- 1.378
- storage temp.
- 2-8°C
- pka
- 8.77±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- CHM0987545
- Product name
- 1,4-DIHYDROXY-2-NAPHTHALENECARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.09
- Updated
- 2021/12/16
- Product number
- CM128377
- Product name
- methyl1,4-dihydroxy-2-naphthoate
- Purity
- 95%
- Packaging
- 1g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- CD41000402
- Product name
- Methyl1,4-dihydroxy-2-naphthoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $356
- Updated
- 2021/12/16
- Product number
- 77060743
- Product name
- Methyl1,4-dihydroxy-2-naphthoate
- Packaging
- 5g
- Price
- $391.02
- Updated
- 2021/12/16
1,4-dihydroxy-2naphthoic acid methyl ester Chemical Properties,Usage,Production
Uses
1,4-dihydroxy-2naphthoic acid methyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
To a stirred solution of LiOt-Bu (3.20 mmol) in THF (10 mL) at -78 ??C(CHCl3-liq N2 bath) under an inert atmosphere was added a solutionof isocyanophthalide (1.0 mmol) in THF (5 mL). The resulting yellowish solution was stirred at -78 ??C for 25 min, after which a solution of a Michael acceptor (1.0-1.5 equiv unless otherwise stated) in THF (5mL) was added. The cooling bath was removed after ca. 1 h at -78 ??C and the mixture was brought to r.t. over a period of 1 h and stirred fora further 2-6 h. The reaction was then quenched with 10% aq NH4Cl(15 mL) and the resulting solution was concentrated. The residue was diluted with EtOAc (50 mL) and the layers were separated. The aqueous layer was extracted with EtOAc (3 ?á 25 mL). The combined extracts were washed with H2O (15 mL) and brine (15 mL), dried (anhydNa2SO4), and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel) or by recrystallizationto obtain the pure product.
1,4-dihydroxy-2naphthoic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-dihydroxy-2naphthoic acid methyl ester manufacturers
- Product
- Methyl 1,4-dihydroxy-2-naphthoate 77060-74-3
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-24
- Product
- Methyl 1,4-dihydroxy-2- naphthoate 77060-74-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-15
- Product
- Methyl 1,4-dihydroxy-2-naphthoate 77060-74-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08