ChemicalBook > CAS DataBase List > 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- Product Name
- 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- CAS No.
- 945260-14-0
- Chemical Name
- 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- Synonyms
- (S)-CGP52421;Midostaurin Impurity 3;Midostaurin Impurity 1;(S)-3-Hydroxy Midostaurin;P37.7 (CGP52421 Epimer 1);(S) 3 Hydroxy Midostaurin,(S)3Hydroxy Midostaurin;3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1);Benzamide, N-[(3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
- CBNumber
- CB45864995
- Molecular Formula
- C35H30N4O5
- Formula Weight
- 586.64
- MOL File
- 945260-14-0.mol
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3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) Property
- Melting point:
- 298-301 °C
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 12.23±0.70(Predicted)
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3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) Chemical Properties,Usage,Production
Uses
(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].
References
[1] Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590. DOI:10.1021/acs.biochem.8b00727
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) Preparation Products And Raw materials
Raw materials
Preparation Products
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945260-14-0, 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)Related Search:
CGP52421
Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
Midostaurin