3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)

Product Name: 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
CAS No.: 155848-20-7
Chemical Name: 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
Synonyms: (R)-CGP52421;Midostaurin Impurity 4;Midostaurin Impurity 2;P39.8 (CGP52421 Epimer 2);(R)-3-Hydroxy Midostaurin;3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2);Benzamide, N-[(3R,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
CBNumber: CB75864996
Molecular Formula: C35H30N4O5
Formula Weight: 586.65
MOL File: 155848-20-7.mol

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3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Property

Density: 1.53±0.1 g/cm3(Predicted)
pka: 12.23±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Chemical Properties,Usage,Production

Uses

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].

References

[1] Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590. DOI:10.1021/acs.biochem.8b00727

3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Preparation Products And Raw materials

Raw materials

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3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Suppliers

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155848-20-7, 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)Related Search:

CGP52421 Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- Midostaurin 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)

3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)

(R)-3-Hydroxy Midostaurin

(R)-CGP52421

Midostaurin Impurity 2

Benzamide, N-[(3R,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-

Midostaurin Impurity 4

P39.8 (CGP52421 Epimer 2)

155848-20-7