ChemicalBook > CAS DataBase List > CGP52421
CGP52421
- Product Name
- CGP52421
- CAS No.
- 179237-49-1
- Chemical Name
- CGP52421
- Synonyms
- 3-Hydroxy Midostaurin;CGP52421;Midostaurin metabolite - CGP52421;3-Hydroxy Midostaurin (CGP 52421);Midostaurin Impurity 1 (3-Hydroxy Midostaurin);3-Hydroxy Midostaurin D5Q: What is 3-Hydroxy Midostaurin D5 Q: What is the CAS Number of 3-Hydroxy Midostaurin D5;Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-;N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide
- CBNumber
- CB92731037
- Molecular Formula
- C35H30N4O5
- Formula Weight
- 586.65
- MOL File
- 179237-49-1.mol
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CGP52421 Property
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 12.23±0.70(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
TRC
- Product number
- H939985
- Product name
- 3-HydroxyMidostaurin
- Packaging
- 2.5mg
- Price
- $180
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0027888
- Product name
- 3-HydroxyMidostaurin
- Packaging
- 5mg
- Price
- $1150
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0027888
- Product name
- 3-HydroxyMidostaurin
- Packaging
- 10mg
- Price
- $1950
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0027888
- Product name
- 3-HydroxyMidostaurin
- Packaging
- 50mg
- Price
- $5500
- Updated
- 2021/12/16
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CGP52421 Chemical Properties,Usage,Production
Uses
3-Hydroxy Midostaurin-d5 is the deuterium labelled 3-Hydroxy Midostaurin (H939985(M)). 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
Biological Activity
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, potently inhibits FMS-like tyrosine kinase 3 (FLT3) autophosphorylation with IC50s of 132 nM and 9.8 μM in culture medium and plasma, respectively. Compared to PKC412, 3-Hydroxy Midostaurin is less selective but more cytotoxic.
in vitro
CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.
target
IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)
CGP52421 Preparation Products And Raw materials
Raw materials
Preparation Products
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179237-49-1, CGP52421Related Search:
Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2)
Midostaurin
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)