CGP52421

Product Name: CGP52421
CAS No.: 179237-49-1
Chemical Name: CGP52421
Synonyms: 3-Hydroxy Midostaurin;CGP52421;Midostaurin metabolite - CGP52421;3-Hydroxy Midostaurin (CGP 52421);Midostaurin Impurity 1 (3-Hydroxy Midostaurin);3-Hydroxy Midostaurin D5Q: What is 3-Hydroxy Midostaurin D5 Q: What is the CAS Number of 3-Hydroxy Midostaurin D5;Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-;N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide
CBNumber: CB92731037
Molecular Formula: C35H30N4O5
Formula Weight: 586.65
MOL File: 179237-49-1.mol

More

Less

CGP52421 Property

Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.23±0.70(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: H939985
Product name: 3-HydroxyMidostaurin
Packaging: 2.5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0027888
Product name: 3-HydroxyMidostaurin
Packaging: 5mg
Price: $1150
Updated: 2021/12/16

ChemScene

Product number: CS-0027888
Product name: 3-HydroxyMidostaurin
Packaging: 10mg
Price: $1950
Updated: 2021/12/16

ChemScene

Product number: CS-0027888
Product name: 3-HydroxyMidostaurin
Packaging: 50mg
Price: $5500
Updated: 2021/12/16

More

Less

CGP52421 Chemical Properties,Usage,Production

Uses

3-Hydroxy Midostaurin-d5 is the deuterium labelled 3-Hydroxy Midostaurin (H939985(M)). 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

Biological Activity

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, potently inhibits FMS-like tyrosine kinase 3 (FLT3) autophosphorylation with IC50s of 132 nM and 9.8 μM in culture medium and plasma, respectively. Compared to PKC412, 3-Hydroxy Midostaurin is less selective but more cytotoxic.

in vitro

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.

target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)

CGP52421 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CGP52421 Suppliers

China 8 India 3 United States 3 Global 14

Artis Biotech Co. Ltd.

Tel: 19138486554 18582380095
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 3066
Advantage: 58

Chengdu Novel Biomedical Co., Ltd.

Tel: 028-85255396 18302801538
Fax: 028-85255396
Email: cdnovell@163.com
Country: China
ProdList: 2238
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5182
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223
Email: psaitong@jm-bio.com
Country: China
ProdList: 29834
Advantage: 58

Aurisco Pharmaceutical (Tianjin) Inc.

Tel: 022-59885855
Email: liuyujie@aurisco.com
Country: China
ProdList: 96
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9241
Advantage: 58

RD International Technology Co., Limited

Tel: 18988968278
Email: sales@ubiochem.com
Country: China
ProdList: 9146
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
Advantage: 58

179237-49-1, CGP52421Related Search:

Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Midostaurin 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)

CGP52421

3-Hydroxy Midostaurin (CGP 52421)

3-Hydroxy Midostaurin

Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-

Midostaurin Impurity 1 (3-Hydroxy Midostaurin)

3-Hydroxy Midostaurin D5Q: What is 3-Hydroxy Midostaurin D5 Q: What is the CAS Number of 3-Hydroxy Midostaurin D5

Midostaurin metabolite - CGP52421

N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide

179237-49-1