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CGP52421

Product Name
CGP52421
CAS No.
179237-49-1
Chemical Name
CGP52421
Synonyms
3-Hydroxy Midostaurin;CGP52421;Midostaurin metabolite - CGP52421;3-Hydroxy Midostaurin (CGP 52421);Midostaurin Impurity 1 (3-Hydroxy Midostaurin);3-Hydroxy Midostaurin D5Q: What is 3-Hydroxy Midostaurin D5 Q: What is the CAS Number of 3-Hydroxy Midostaurin D5;Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-;N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide
CBNumber
CB92731037
Molecular Formula
C35H30N4O5
Formula Weight
586.65
MOL File
179237-49-1.mol
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CGP52421 Property

Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
12.23±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
H939985
Product name
3-HydroxyMidostaurin
Packaging
2.5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0027888
Product name
3-HydroxyMidostaurin
Packaging
5mg
Price
$1150
Updated
2021/12/16
ChemScene
Product number
CS-0027888
Product name
3-HydroxyMidostaurin
Packaging
10mg
Price
$1950
Updated
2021/12/16
ChemScene
Product number
CS-0027888
Product name
3-HydroxyMidostaurin
Packaging
50mg
Price
$5500
Updated
2021/12/16
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CGP52421 Chemical Properties,Usage,Production

Uses

3-Hydroxy Midostaurin-d5 is the deuterium labelled 3-Hydroxy Midostaurin (H939985(M)). 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

Biological Activity

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, potently inhibits FMS-like tyrosine kinase 3 (FLT3) autophosphorylation with IC50s of 132 nM and 9.8 μM in culture medium and plasma, respectively. Compared to PKC412, 3-Hydroxy Midostaurin is less selective but more cytotoxic.

in vitro

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.

target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)

CGP52421 Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP52421 Suppliers

China 9 India 3 United States 4 Global 16
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58

179237-49-1, CGP52421Related Search:

Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) Midostaurin 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)

  • CGP52421
  • 3-Hydroxy Midostaurin (CGP 52421)
  • 3-Hydroxy Midostaurin
  • Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-
  • Midostaurin Impurity 1 (3-Hydroxy Midostaurin)
  • 3-Hydroxy Midostaurin D5Q: What is 3-Hydroxy Midostaurin D5 Q: What is the CAS Number of 3-Hydroxy Midostaurin D5
  • Midostaurin metabolite - CGP52421
  • N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide
  • 179237-49-1