MINAPRINE DIHYDROCHLORIDE

Product Name: MINAPRINE DIHYDROCHLORIDE
CAS No.: 25905-77-5
Chemical Name: MINAPRINE DIHYDROCHLORIDE
Synonyms: minaprine;TS-370;Cantor;minaprin;Minaprina;Minaprinum;Minaprin diHCl;Minaprine 2HCl;MINAPRINE HYDROCHLORIDE;MINAPRIN DIHYDROCHLORIDE
CBNumber: CB4686336
Molecular Formula: C17H22N4O
Formula Weight: 298.38
MOL File: 25905-77-5.mol

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MINAPRINE DIHYDROCHLORIDE Property

Melting point:: 122°
Boiling point:: 531.2±50.0 °C(Predicted)
Density: 1.156±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 35 mg/mL (117.30 mM)
pka: 6.80±0.10(Predicted)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: QE3477830

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M3157
Product name: Minaprine dihydrochloride
Purity: analytical standard
Packaging: 1g
Price: $61.4
Updated: 2022/05/15

TRC

Product number: M345203
Product name: Minaprine
Packaging: 2.5g
Price: $85
Updated: 2021/12/16

Usbiological

Product number: 456242
Product name: Minaprine
Packaging: 1g
Price: $305
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009128
Product name: MINAPRINE
Purity: 95.00%
Packaging: 1G
Price: $654.16
Updated: 2021/12/16

CSNpharm

Product number: CSN18166
Product name: Minaprine
Packaging: 25mg
Price: $35
Updated: 2021/12/16

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MINAPRINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Cantor,Clin Midy,France,1979

Uses

Minaprine is a central nervous system (CNS) drug through the use of analog synthesis and CYP2D6 enzyme kinetic analyses.

Uses

muscle relaxant (skeletal)

Definition

ChEBI: Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug.

Manufacturing Process

(a) Preparation of the free base: A mixture comprising 0.1 mol (20.4 g) of 3-chloro-4-methyl-6-phenylpyridazine and 0.2 mol (26.2 g) of N-(2-aminoethyl)-morpholine in 100 ml of n-butanol, with a pinch of copper powder, was heatedunder reflux for 12 hours. At the end of this time, the hot solution was pouredinto 200 ml of cold water. The resulting mixture was filtered through asintered glass filter and the precipitate washed with ether. The filtrate and theether washings were placed in a separating funnel and extracted with two 150ml portions of ether. The ethereal layer was then extracted with about 250 mlof N sulfuric acid.
The acid solution was made alkaline with a 10% aqueous solution of sodiumcarbonate, and left to crystallize overnight.
The solution was filtered, yielding the colorless needles which wererecrystallized from isopropanol. The yield was 15 g (53%).
(b) Preparation of the hydrochloride: The base was dissolved in the smallestamount possible of anhydrous acetone. Double that volume of anhydrousether was added, and a stream of hydrogen chloride gas was passed throughthe solution. The hydrochloride salt obtained was recrystallized from absolutealcohol. The yield after recrystallization was 17 g (90%).

brand name

Cantor (Sanofi).

Therapeutic Function

Antidepressant

MINAPRINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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MINAPRINE DIHYDROCHLORIDE Suppliers

China 29 Germany 1 South Korea 1 Switzerland 1 United Kingdom 5 United States 13 Global 50

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25905-77-5, MINAPRINE DIHYDROCHLORIDERelated Search:

Bazinaprine Moxiraprine MINAPRINE DIHYDROCHLORIDE

n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamin

n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine

minaprin

Minaprin diHCl

N-(4-Methyl-6-phenylpyridazin-3-yl)-4-morpholineethanamine

TS-370

N-[4-METHYL-6-PHENYL-3-PYRIDAZINYL]-4-MORPHOLINEETHANAMINE DIHYDROCHLORIDE

MINAPRIN DIHYDROCHLORIDE

MINAPRINE DIHYDROCHLORIDE

MINAPRINE HYDROCHLORIDE

Minaprine 2HCl

minaprine

Cantor

Minaprina

Minaprinum

4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-

4-Methyl-N-(2-morpholinoethyl)-6-phenylpyridazin-3-amine , Minaprine

25905-77-5

C17H22N4O

C17H22N4O2HCl

METI - MZ

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