5-METHOXYFLAVONE
- Product Name
- 5-METHOXYFLAVONE
- CAS No.
- 42079-78-7
- Chemical Name
- 5-METHOXYFLAVONE
- Synonyms
- 5-METHOXYFLAVONE;METHOXYFLAVONE, 5-;5-Methoxy flavonone;5-Methoxyflavone>5-Methoxyflavone,97%;5-methoxy-2-phenyl-chromone;5-methoxy-2-phenylchromen-4-one;5-methoxy-2-phenyl-4-benzopyrone;5-methoxy-2-phenyl-chromen-4-one;5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
- CBNumber
- CB4688875
- Molecular Formula
- C16H12O3
- Formula Weight
- 252.26
- MOL File
- 42079-78-7.mol
5-METHOXYFLAVONE Property
- Melting point:
- 131-133°C
- Boiling point:
- 422.5±45.0 °C(Predicted)
- Density
- 1,155g/cm
- refractive index
- 1,548
- storage temp.
- Store at -20°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Almost white
- LogP
- 3.470 (est)
- CAS DataBase Reference
- 42079-78-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36
- WGK Germany
- 3
- HS Code
- 2932.99.7000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2365
- Product name
- 5-Methoxyflavone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $91
- Updated
- 2024/03/01
- Product number
- M2365
- Product name
- 5-Methoxyflavone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $271
- Updated
- 2024/03/01
- Product number
- B23700
- Product name
- 5-Methoxyflavone, 97%
- Packaging
- 0.1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- B23700
- Product name
- 5-Methoxyflavone, 97%
- Packaging
- 0.5g
- Price
- $66.6
- Updated
- 2021/12/16
- Product number
- B23700
- Product name
- 5-Methoxyflavone, 97%
- Packaging
- 2.5g
- Price
- $279
- Updated
- 2021/12/16
5-METHOXYFLAVONE Chemical Properties,Usage,Production
Uses
5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation.
Definition
ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids.
Biological Activity
5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors.
in vitro
5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner.
in vivo
5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals.
target
| Target | Value |
| DNA polymerase β () |
5-METHOXYFLAVONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHOXYFLAVONE manufacturers
- Product
- 5-methoxyflavone 42079-78-7
- Price
- US $600.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-04-23
- Product
- 5-Methoxyflavone 42079-78-7
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-25