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5-METHOXYFLAVONE

Product Name
5-METHOXYFLAVONE
CAS No.
42079-78-7
Chemical Name
5-METHOXYFLAVONE
Synonyms
5-METHOXYFLAVONE;METHOXYFLAVONE, 5-;5-Methoxy flavonone;5-Methoxyflavone>5-Methoxyflavone,97%;5-methoxy-2-phenyl-chromone;5-methoxy-2-phenylchromen-4-one;5-methoxy-2-phenyl-4-benzopyrone;5-methoxy-2-phenyl-chromen-4-one;5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
CBNumber
CB4688875
Molecular Formula
C16H12O3
Formula Weight
252.26
MOL File
42079-78-7.mol
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5-METHOXYFLAVONE Property

Melting point:
131-133°C
Boiling point:
422.5±45.0 °C(Predicted)
Density 
1,155g/cm
refractive index 
1,548
storage temp. 
Store at -20°C
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Almost white
LogP
3.470 (est)
CAS DataBase Reference
42079-78-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-36
WGK Germany 
3
HS Code 
2932.99.7000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2365
Product name
5-Methoxyflavone
Purity
>98.0%(GC)
Packaging
1g
Price
$91
Updated
2024/03/01
TCI Chemical
Product number
M2365
Product name
5-Methoxyflavone
Purity
>98.0%(GC)
Packaging
5g
Price
$271
Updated
2024/03/01
Alfa Aesar
Product number
B23700
Product name
5-Methoxyflavone, 97%
Packaging
0.1g
Price
$22
Updated
2021/12/16
Alfa Aesar
Product number
B23700
Product name
5-Methoxyflavone, 97%
Packaging
0.5g
Price
$66.6
Updated
2021/12/16
Alfa Aesar
Product number
B23700
Product name
5-Methoxyflavone, 97%
Packaging
2.5g
Price
$279
Updated
2021/12/16
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5-METHOXYFLAVONE Chemical Properties,Usage,Production

Uses

5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation.

Definition

ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids.

Biological Activity

5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors.

in vitro

5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner.

in vivo

5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals.

target

TargetValue
DNA polymerase β
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5-METHOXYFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHOXYFLAVONE Suppliers

Americas 1 Canada 1 China 64 Europe 1 Germany 3 India 7 Japan 2 Switzerland 1 United Kingdom 8 United States 16 USA 1 Global 105
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from 5-METHOXYFLAVONE manufacturers

R&D Scientific Inc.
Product
5-methoxyflavone 42079-78-7
Price
US $600.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-04-23
Career Henan Chemical Co
Product
5-Methoxyflavone 42079-78-7
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

42079-78-7, 5-METHOXYFLAVONERelated Search:

5,6,7-TRIMETHOXYFLAVONE SCUTELLAREIN TETRAMETHYL ETHER 3',4',5',5,7-PENTAMETHOXYFLAVONE Tangeretin 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE 5-O-Methyl Quercetin;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-5-Methoxy-4H-1-benzopyran-4-one 5-METHOXYFLAVONE 5,7-DIMETHOXYFLAVONE 3,5-DIMETHOXYFLAVONE EUPATORIN-5-METHYL ETHER 3-HYDROXY-5-METHOXYFLAVONE 3',4',5',5,6,7-HEXAMETHOXYFLAVONE Diosmetin 4',5,7-TRIHYDROXY-3'-METHOXYFLAVONE 3-HYDROXY-7-METHOXYFLAVONE 4',5-DIHYDROXY-7-METHOXYFLAVONE,5,4'-DIHYDROXY-7-METHOXYFLAVONE 5,6-DIHYDROXY-7-METHOXYFLAVONE 3-HYDROXY-6-METHOXYFLAVONE

  • METHOXYFLAVONE, 5-
  • 5-METHOXYFLAVONE
  • 5-methoxy-2-phenyl-4-benzopyrone
  • 5-Methoxyflavone,97%
  • 5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
  • 5-methoxy-2-phenyl-chromen-4-one
  • 5-methoxy-2-phenylchromen-4-one
  • 5-methoxy-2-phenyl-chromone
  • 5-Methoxyflavone&gt
  • 4H-1-Benzopyran-4-one, 5-methoxy-2-phenyl-
  • 5-Methoxy flavonone
  • 5 methoxyflavone,5methoxyflavone,Inhibitor,inhibit,DNA/RNA Synthesis,5-Methoxyflavone
  • 42079-78-7
  • Benzopyrans
  • Building Blocks
  • Heterocyclic Building Blocks
  • Mono-substituted Flavones