5-METHOXYFLAVONE

ChemicalBook > CAS DataBase List > 5-METHOXYFLAVONE

Product Name: 5-METHOXYFLAVONE
CAS No.: 42079-78-7
Chemical Name: 5-METHOXYFLAVONE
Synonyms: 5-METHOXYFLAVONE;METHOXYFLAVONE, 5-;5-Methoxy flavonone;5-Methoxyflavone>5-Methoxyflavone,97%;5-methoxy-2-phenyl-chromone;5-methoxy-2-phenylchromen-4-one;5-methoxy-2-phenyl-4-benzopyrone;5-methoxy-2-phenyl-chromen-4-one;5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
CBNumber: CB4688875
Molecular Formula: C16H12O3
Formula Weight: 252.26
MOL File: 42079-78-7.mol

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5-METHOXYFLAVONE Property

Melting point:: 131-133°C
Boiling point:: 422.5±45.0 °C(Predicted)
Density: 1,155g/cm
refractive index: 1,548
storage temp.: Store at -20°C
solubility: soluble in Methanol
form: powder to crystal
color: White to Almost white
LogP: 3.470 (est)
CAS DataBase Reference: 42079-78-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-36
WGK Germany: 3
HS Code: 2932.99.7000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2365
Product name: 5-Methoxyflavone
Purity: >98.0%(GC)
Packaging: 1g
Price: $91
Updated: 2024/03/01

TCI Chemical

Product number: M2365
Product name: 5-Methoxyflavone
Purity: >98.0%(GC)
Packaging: 5g
Price: $271
Updated: 2024/03/01

Alfa Aesar

Product number: B23700
Product name: 5-Methoxyflavone, 97%
Packaging: 0.1g
Price: $22
Updated: 2021/12/16

Alfa Aesar

Product number: B23700
Product name: 5-Methoxyflavone, 97%
Packaging: 0.5g
Price: $66.6
Updated: 2021/12/16

Alfa Aesar

Product number: B23700
Product name: 5-Methoxyflavone, 97%
Packaging: 2.5g
Price: $279
Updated: 2021/12/16

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5-METHOXYFLAVONE Chemical Properties,Usage,Production

Uses

5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation.

Definition

ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids.

Biological Activity

5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors.

in vitro

5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner.

in vivo

5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals.

target

Target	Value
DNA polymerase β ()

5-METHOXYFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-METHOXYFLAVONE manufacturers

R&D Scientific Inc.

Product: 5-methoxyflavone 42079-78-7
Price: US $600.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-04-23

Career Henan Chemical Co

Product: 5-Methoxyflavone 42079-78-7
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-25

42079-78-7, 5-METHOXYFLAVONERelated Search:

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42079-78-7

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