4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

Product Name: 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
CAS No.: 287930-73-8
Chemical Name: 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
Synonyms: -2-hydroxymorphoL;Aprepitant Impurity 48;Fosaprepitant Impurity B;Fosaprepitant Impurity 23;4-Benzyl-2-hydroxy-3-morpholinone;4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE;2-Hydroxy-4-(benzyl)morpholin-3-one;4- benzyl -2- hydroxymorpholine -3- one;2-Hydroxy-4-(phenylMethyl)-3-Morpholinone;3-Morpholinone,2-hydroxy-4-(phenylMethyl)-
CBNumber: CB4690014
Molecular Formula: C11H13NO3
Formula Weight: 207.23
MOL File: 287930-73-8.mol

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4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Property

Melting point:: 134.0 to 138.0 °C
Boiling point:: 441.7±45.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 11.00±0.20(Predicted)
color: White to Off-White
optical activity: 0.30°(C=0.01g/ml CHCL3)

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Safety

HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4918
Product name: 4-Benzyl-2-hydroxymorpholin-3-one
Purity: >98.0%(GC)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: B4918
Product name: 4-Benzyl-2-hydroxymorpholin-3-one
Purity: >98.0%(GC)
Packaging: 5g
Price: $65
Updated: 2025/07/31

TRC

Product number: H950915
Product name: 2-Hydroxy-4-(phenylmethyl)-3-morpholinone
Packaging: 500mg
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: J54248
Product name: 4-Benzyl-2-hydroxymorpholin-3-one
Packaging: 1g
Price: $20
Updated: 2021/12/16

Chem-Impex

Product number: 43126
Product name: 4-Benzyl-2-hydroxymorpholin-3-one,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $20.8
Updated: 2021/12/16

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4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Chemical Properties,Usage,Production

Uses

2-Hydroxy-4-(phenylmethyl)-3-morpholinone, is an intermediate used for the synthesis of NK1 Receptor Antagonist Aprepitant (A729800), used as as antiemetic drugs.

Synthesis

298-12-4

104-63-2

287930-73-8

A 50% aqueous solution of glyoxalate (67 mL, 0.61 mol) and tetrahydrofuran (130 mL) were added to a 250 mL round bottom flask and heated to reflux. A solution of N-benzylethanolamine (41.5 g, 0.27 mol) in tetrahydrofuran (20 mL) was slowly added dropwise under reflux conditions. After completion of the reaction, the tetrahydrofuran solvent was removed by rotary evaporator. Water (170 mL) was added to the residue, stirred and cooled to room temperature, followed by continued stirring in an ice water bath for 30 min to promote crystallization. The precipitated solid was collected by filtration and washed with ice water. The resulting pale yellow solid was dried to afford the target product 4-benzyl-2-hydroxy-morpholin-3-one (compound of formula VII, 51.8 g, 91% yield) with a melting point of 132-136 °C.

References

[1] Patent: CN103030668, 2016, B. Location in patent: Paragraph 0031-0033
[2] Journal of the American Chemical Society, 2003, vol. 125, # 8, p. 2129 - 2135

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Suppliers

Americas 1 China 197 China Hong Kong 1 Europe 1 India 4 Japan 1 United Kingdom 1 United States 11 Global 217

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Adamas Reagent, Ltd.

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Shanghai Sphchem Co., Ltd.

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Wisdom Pharmaceutical Co., Ltd.

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View Lastest Price from 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE manufacturers

Hebei Dangtong Import and export Co LTD

Product: 287930-73-8 287930-73-8
Price: US $100.00-60.00/kg
Min. Order: 100kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-06

Hangzhou ICH Biofarm Co., Ltd

Product: 4-Benzyl-2-hydroxy-3-morpholinone 287930-73-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200
Release date: 2023-07-18

Anhui Ruihan Technology Co., Ltd

Product: 4-Benzyl-2-hydroxy-3-morpholinone 287930-73-8
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-09-07

287930-73-8, 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONERelated Search:

Fosaprepitant Benzyl Ester Aprepitant Aprepitant Fosaprepitant Impurity 6 (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Aprepitant Fosaprepitant Impurity 5 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one 1,1,1-Trimethoxy-2-chloroethane Aprepitant (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 4-BENZYL-MORPHOLIN-3-ONE 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

Aprepitant Impurity 48

Fosaprepitant Impurity 23

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

3-Morpholinone,2-hydroxy-4-(phenylMethyl)-

2-Hydroxy-4-(phenylMethyl)-3-Morpholinone

Fosaprepitant Impurity B

-2-hydroxymorphoL

Aprepitant intermediates，4-Benzyl-2-hydroxy-morpholin-3-one

TIANFUCHEM--287930-73-8--High purity 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE factory price

4- benzyl -2- hydroxymorpholine -3- one

4-Benzyl-2-hydroxy-3-morpholinone

2-Hydroxy-4-(benzyl)morpholin-3-one

287930-73-8

pharmacetical