ChemicalBook > CAS DataBase List > Benzamidine hydrochloride hydrate

Benzamidine hydrochloride hydrate

Product Name
Benzamidine hydrochloride hydrate
CAS No.
206752-36-5
Chemical Name
Benzamidine hydrochloride hydrate
Synonyms
BENZAMIDINE HCL HYDRATE;Imino(phenyl)methylamine;BENZAMIDINIUM CHLORIDE HYDRATE;BENZAMIDINE HYDROCHLORIDE HYDRATE;[amino(phenyl)methylidene]azanium;BENZAMIDINE HYDROCHLORIDE N-HYDRATE;AMIDINOBENZENE HYDROCHLORIDE HYDRATE;BENZAMIDINE HYDROCHLORIDE HYDRATE FO;BENZAMIDINE HYDROCHLORIDE MONOHYDRATE;Benzamidine hydrochloride hydrate,98%
CBNumber
CB4694173
Molecular Formula
C7H11ClN2O
Formula Weight
174.63
MOL File
206752-36-5.mol
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Benzamidine hydrochloride hydrate Property

Melting point:
86-88 °C(lit.)
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL, clear to slightly hazy, colorless to faintly yellow
form 
Powder
color 
White to off-white
PH
5 (50g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
3594959
CAS DataBase Reference
206752-36-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
CV6260000
F 
3-21
TSCA 
Yes
HS Code 
2925 29 00
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.20122
Product name
Benzamidine hydrochloride hydrate
Purity
for synthesis
Packaging
2g
Price
$41.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20122
Product name
Benzamidine hydrochloride hydrate
Purity
for synthesis
Packaging
25g
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20122
Product name
Benzamidine hydrochloride hydrate
Purity
for synthesis
Packaging
1kg
Price
$1250
Updated
2024/03/01
Alfa Aesar
Product number
A16002
Product name
Benzamidine hydrochloride hydrate, 98%, water ca 10-14%
Packaging
5g
Price
$27.65
Updated
2024/03/01
Alfa Aesar
Product number
A16002
Product name
Benzamidine hydrochloride hydrate, 98%, water ca 10-14%
Packaging
25g
Price
$78
Updated
2024/03/01
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Benzamidine hydrochloride hydrate Chemical Properties,Usage,Production

Chemical Properties

white fine crystalline powder

Uses

Benzamidine hydrochloride hydrate is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. It is a proteolytic inhibitor and apoptosis reagent.

Uses

Benzamidine hydrochloride hydrate has been used:

  • in western blot analysis
  • in immunoprecipitation
  • in the purification of yeast dynein
  • as a protease inhibitor in the preparation of brush-border membrane vesicles
  • for the processing of human synovial fluid, blood and eye sleep
  • to prevent non-specific degradation of cartilages

Application

Benzamidine hydrochloride hydrate has been used:
in western blot analysis
in immunoprecipitation
in the purification of yeast dynein
as a protease inhibitor in the preparation of brush-border membrane vesicles
for the processing of human synovial fluid, blood and eye sleep
to prevent non-specific degradation of cartilages

Biological Activity

Peptidase inhibitor.
Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases.A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.

Biochem/physiol Actions

Peptidase inhibitor.

Purification Methods

Recrystallise it from dilute HCl (crystals contain xH2O) or EtOH/few drops HCl; dry it in a vacuum. It is a proteolytic inhibitor [Jeffcoate & White J Clin Endocrinol Metab 38 155 1974, Beilstein 9 IV 898.]

Preparation and handling

Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.

Precautions

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is hygroscopic in nature.

Benzamidine hydrochloride hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzamidine hydrochloride hydrate Suppliers

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View Lastest Price from Benzamidine hydrochloride hydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Benzamidine hydrochloride hydrate 206752-36-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
5000kgs/month
Release date
2021-10-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
Benzamidine hydrochloride hydrate 206752-36-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
Benzamidine hydrochloride hydrate 206752-36-5
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

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  • BENZAMIDINE HYDROCHLORIDE HYDRATE FO
  • [amino(phenyl)methylidene]azanium
  • Imino(phenyl)methylamine
  • 206752-36-5
  • C7H8N2ClHH2O
  • C7H8N2HClH2O
  • C7H8N2HClxH2O
  • C7H8N26HClxH2O
  • C7H9N2