3-Hydroxy-4-methoxyphenylacetic acid
- Product Name
- 3-Hydroxy-4-methoxyphenylacetic acid
- CAS No.
- 1131-94-8
- Chemical Name
- 3-Hydroxy-4-methoxyphenylacetic acid
- Synonyms
- Isohomovanillic acid;isohomovanillicaci;HOMOISOVANILLIC ACID;3-Hydroxy-4-methoxyphenyL;3-HYDROXY-4-METHOXYPHENYLACETIC ACID;4-Methoxy-3-hydroxyphenylacetic Acid;3-Hydroxy-4-Methoxybenzeneacetic Acid;3-Hydroxy-4-methoxyphenylaceticAcid>3-Hydroxy-4-methoxyphenylacetic acid 97%;Benzeneacetic acid, 3-hydroxy-4-methoxy-
- CBNumber
- CB4694502
- Molecular Formula
- C9H10O4
- Formula Weight
- 182.17
- MOL File
- 1131-94-8.mol
3-Hydroxy-4-methoxyphenylacetic acid Property
- Melting point:
- 127-132 °C
- Boiling point:
- 371.3±27.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.36±0.10(Predicted)
- color
- Pale Beige
- CAS DataBase Reference
- 1131-94-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 716391
- Product name
- 3-Hydroxy-4-methoxyphenylacetic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $25.55
- Updated
- 2025/07/31
- Product number
- H1455
- Product name
- 3-Hydroxy-4-methoxyphenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $66
- Updated
- 2025/07/31
- Product number
- H1455
- Product name
- 3-Hydroxy-4-methoxyphenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $262
- Updated
- 2025/07/31
- Product number
- 014002
- Product name
- 3-Hydroxy-4-methoxyphenylacetic Acid
- Packaging
- 1g
- Price
- $319
- Updated
- 2021/12/16
- Product number
- H946410
- Product name
- 3-Hydroxy-4-methoxyphenylacetic acid
- Packaging
- 10g
- Price
- $225
- Updated
- 2021/12/16
3-Hydroxy-4-methoxyphenylacetic acid Chemical Properties,Usage,Production
Chemical Properties
Pale Beige Solid
Uses
3-Hydroxy-4-methoxyphenylacetic acid is a 4-O-methylated metabolite of catechol amines in man. 3-Hydroxy-4-methoxyphenylacetic acid is also a metabolite of 3,4-dihydroxyphenylalanine (DOPA) analogues as well as a metabolite of Hydroxytyrosol (H977000).
Definition
ChEBI: A monocarboxylic acid that is the 4-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 2061, 1984 DOI: 10.1021/jo00185a061
Synthesis
774-81-2
1131-94-8
General procedure for the synthesis of 3-hydroxy-4-methoxyphenylacetic acid from 3-bromo-4-methoxyphenylacetic acid: sodium hydroxide (24.5 g, 612 mmol) and copper sulfate pentahydrate (1.02 g, 4.08 mmol) were added to a 125 mL sealed tube, followed by the addition of water (60 mL) to dissolve. The mixture was cooled and 3-bromo-4-methoxyphenylacetic acid (10 g, 40.8 mmol) was added. The reaction tube was sealed and placed in an oil bath at 150°C with stirring for 20 hours. After completion of the reaction, it was cooled to room temperature and the pH was adjusted slowly and dropwise to 3 by adding concentrated hydrochloric acid.The reaction mixture was filtered by pumping and the filter cake was washed with water. The collected solid was purified by column chromatography (eluent: dichloromethane/methanol, 30:1, v/v) to give an off-white solid product (3.3 g, 44.4% yield).
IC 50
Human Endogenous Metabolite
References
[1] Journal of Organic Chemistry, 1984, vol. 49, # 11, p. 2061 - 2063
[2] Synthesis, 2011, # 2, p. 217 - 222
[3] Patent: WO2010/75469, 2010, A1. Location in patent: Page/Page column 115
[4] Patent: US2011/9628, 2011, A1. Location in patent: Page/Page column 37
[5] Patent: CN105481849, 2016, A. Location in patent: Paragraph 0461; 0465; 0466
3-Hydroxy-4-methoxyphenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Hydroxy-4-methoxyphenylacetic acid Suppliers
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View Lastest Price from 3-Hydroxy-4-methoxyphenylacetic acid manufacturers
- Product
- isohomovanillic acid 1131-94-8
- Price
- US $10.70/kg
- Min. Order
- 10kg
- Purity
- 99.5%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20
- Product
- 3-Hydroxy-4-methoxyphenylacetic acid 1131-94-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 5000KG
- Release date
- 2024-07-18