1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE

Product Name: 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
CAS No.: 75629-57-1
Chemical Name: 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
Synonyms: CS-1229;Oncrasin 1;ZERO/008607;AKOS B014321;ZINC00439476;Oncrasin 1 >ASISCHEM N15726;ART-CHEM-BB B014321;CHEMBRDG-BB 5601604;Oncrasin-1, 10 mM in DMSO
CBNumber: CB4698434
Molecular Formula: C16H12ClNO
Formula Weight: 269.73
MOL File: 75629-57-1.mol

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1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Property

Melting point:: 115.0 to 119.0 °C
Boiling point:: 465.5±30.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: ≥20mg/mL
form: powder
color: off-white to light tan
Sensitive: Light Sensitive

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Safety

Hazard Codes: Xi
WGK Germany: 3
HS Code: 2933.99.9000
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 496265
Product name: Oncrasin-1
Packaging: 25mg
Price: $128
Updated: 2023/06/20

Sigma-Aldrich

Product number: O0516
Product name: Oncrasin-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $109
Updated: 2022/05/15

TCI Chemical

Product number: O0450
Product name: Oncrasin 1
Purity: >95.0%(HPLC)
Packaging: 10mg
Price: $112
Updated: 2024/03/01

TCI Chemical

Product number: O0450
Product name: Oncrasin 1
Purity: >95.0%(HPLC)
Packaging: 50mg
Price: $390
Updated: 2024/03/01

Alfa Aesar

Product number: J64018
Product name: Oncrasin 1
Packaging: 10mg
Price: $128
Updated: 2021/12/16

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1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Chemical Properties,Usage,Production

Uses

Oncrasin 1 is a proapoptotic compound.

Definition

ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.

Biological Activity

Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .

storage

+4°C

1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Suppliers

Americas 1 China 86 Europe 1 Germany 2 India 1 Japan 1 Russia 2 United Kingdom 4 United States 19 Global 117

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75629-57-1, 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDERelated Search:

Indibulin 1-(3,4-DICHLORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE ASISCHEM R41968 1-(2,4-DICHLORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE 1-(2-CHLORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE 1-(4-CHLOROBENZYL)-N-PHENYL-1H-INDOLE-3-CARBOXAMIDE METHYL 1-(2,4-DICHLOROBENZOYL)-1H-INDOLE-3-CARBOXYLATE METHYL 1-(4-CHLOROBENZOYL)-1H-INDOLE-3-CARBOXYLATE CBI-BB ZERO/008374 CBI-BB ZERO/005692 1-(4-CHLOROBENZYL)-N-(4-METHOXYPHENYL)-1H-INDOLE-3-CARBOXAMIDE 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(2,4-DICHLOROPHENYL)METHYL]-,METHYL ESTER ASISCHEM V95851 1-(4-CHLOROBENZYL)-1H-INDOLE-3-CARBOXYLIC ACID 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(3,4-DICHLOROPHENYL)METHYL]-, METHYL ESTER 5-BROMO-1-(4-CHLOROBENZYL)-1H-INDOLE-3-CARBALDEHYDE N-BENZYL-1-(4-CHLOROBENZYL)-1H-INDOLE-3-CARBOXAMIDE

1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE

AKOS B014321

CHEMBRDG-BB 5601604

ART-CHEM-BB B014321

ASISCHEM N15726

Oncrasin 1

1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde

1-(4-chlorobenzyl)-1H-indole-3-carbaldehyde(SALTDATA: FREE)

1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde

CS-1229

Oncrasin-1 - CAS 75629-57-1 - Calbiochem

1-[(4-chlorophenyl)methyl]-3-indolecarboxaldehyde

ZERO/008607

ZINC00439476

1-[(4-chlorophenyl)methyl]indole-3-carbaldehyde

1-(4-chlorobenzyl)indole-3-carbaldehyde

Oncrasin 1 &gt

1H-Indole-3-carboxaldehyde, 1-[(4-chlorophenyl)methyl]-

1-(4-Chlorobenzyl)-1H-indole-3-carboxaldehyde

Oncrasin-1, 10 mM in DMSO

75629-57-1

C16H12CINO

Apoptosis Inducers