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p-Acetotoluidide

Product Name
p-Acetotoluidide
CAS No.
103-89-9
Chemical Name
p-Acetotoluidide
Synonyms
NSC 7644;4-Acetotoluide;p-Acetotoluide;p-Tolyacetamide;P-TOLYLACETAMIDE;P-ACETOTOLUIDINE;P-ACETOTOLUIDIDE;ACET-P-TOLUIDINE;4-ACETOTOLUIDINE;4-Acetotoluidide
CBNumber
CB4703774
Molecular Formula
C9H11NO
Formula Weight
149.19
MOL File
103-89-9.mol
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p-Acetotoluidide Property

Melting point:
149-151 °C(lit.)
Boiling point:
307 °C(lit.)
Density 
1.21
vapor density 
5.14
refractive index 
1.5279 (estimate)
Flash point:
168 °C
storage temp. 
Store below +30°C.
solubility 
1.2g/l (experimental)
pka
15.13±0.70(Predicted)
form 
Crystals or Crystalline Powder
color 
Beige to light brown
Water Solubility 
1 g/L (25 ºC)
Merck 
14,74
BRN 
607036
InChIKey
YICAMJWHIUMFDI-UHFFFAOYSA-N
CAS DataBase Reference
103-89-9(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, N-(4-methylphenyl)-(103-89-9)
EPA Substance Registry System
p-Acetotoluidide (103-89-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AN2930000
TSCA 
Yes
HS Code 
29242995
Toxicity
LD50 orl-rat: 2640 mg/kg MarJV# 29MAR77
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
307076
Product name
4′-Methylacetanilide
Purity
99%
Packaging
10g
Price
$22.1
Updated
2021/03/22
Sigma-Aldrich
Product number
307076
Product name
4′-Methylacetanilide
Purity
99%
Packaging
100g
Price
$61.2
Updated
2021/03/22
Sigma-Aldrich
Product number
8.00077
Product name
4′-Methylacetanilide
Purity
for synthesis
Packaging
250 g
Price
$119.32
Updated
2021/03/22
TCI Chemical
Product number
A0064
Product name
p-Acetotoluidine
Purity
>98.0%(GC)
Packaging
25g
Price
$49
Updated
2021/03/22
TCI Chemical
Product number
A0064
Product name
p-Acetotoluidine
Purity
>98.0%(GC)
Packaging
100g
Price
$143
Updated
2021/03/22
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p-Acetotoluidide Chemical Properties,Usage,Production

Description

p-Acetotoluidide is an off-white to brown flake, odourless, solid or crystalline powder (pure form), which is soluble in hot water, alcohol, ether, chloroform, acetone, glycerol, and benzene. It is combustible and undergoes self-ignition (at 5450°C) but is otherwise stable under most conditions. p-Acetanilide on decomposition releases carbon monoxide, oxides of nitrogen, carbon dioxide, and toxic fumes. p-Acetanilide is used as an inhibitor of peroxides and stabiliser for cellulose ester varnishes. It is used as an intermediate for the synthesis of rubber accelerators, dyes and dye intermediate, and camphor. It is also used as a precursor in penicillin synthesis and other pharmaceuticals including painkillers and intermediates. Phenylacetamide structure shows analgesic and antipyretic effects. But acetanilide is not used directly for this application due to causing methemoglobinemia (the presence of excessive methemoglobin which does not function reversibly as an oxygen carrier in the blood).

Chemical Properties

BEIGE TO LIGHT BROWN CRYSTALS OR CRYST. POWDER

Chemical Properties

p-Acetotoluidide is an off-white to brown fl ake, odorless, solid or crystalline powder (pure form), soluble in hot water alcohol, ether, chloroform, acetone, glycerol, and benzene. It is combustible and undergoes self-ignition (at 545°C), but is otherwise stable under most conditions. On decomposition, p-acetanilide releases carbon monoxide, oxides of nitrogen, carbon dioxide, and toxic fumes. p-Acetanilide is used as an inhibitor of peroxides and a stabilizer for cellulose ester varnishes. It is used as an intermediate for the synthesis of rubber accelerators, dyes and dye intermediate, and camphor. It is also used as a precursor in penicillin synthesis and other pharmaceuticals, including painkillers and intermediates. Phenylacetamide structure shows analgesic and antipyretic effects. But acetanilide is not used directly for this application because it causes methemoglobinemia (the presence of excessive methemoglobin that does not function reversibly as an oxygen carrier in the blood).

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 5092, 1955 DOI: 10.1021/ja01624a042
Organic Syntheses, Coll. Vol. 1, p. 111, 1941
Synthesis, p. 118, 1977

General Description

Colorless needles.

Air & Water Reactions

Water insoluble.

Reactivity Profile

4'-Methylacetanilide is an amide. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 4'-Methylacetanilide emits toxic fumes.

Health Hazard

Exposures to p-acetotoluidide through ingestion or inhalation cause potential health effects. The symptoms of toxicity include, but are not limited to, irritation to the eyes and redness of the skin, wheezing, cough, shortness of breath, or burning in the mouth, throat, or chest, and respiratory tract irritation.

Safety Profile

Moderately toxic by ingestion. See also ACETANILIDE. Combustible. When heated to decomposition it emits toxic fumes of NO,. To fight fire, use water, foam, CO2, dry chemical

storage

p-Acetanilide should be kept stored in a cool, dry place with the container closed when not in use

Purification Methods

Crystallise it from aqueous EtOH. [Beilstein 12 H 920, 12 I 420, 12 II 501, 12 III 2051, 12 IV 1902.]

Precautions

During handling and use of p-aetotoluidide, proper personal protective equipment should be worn. Avoid contact with the eyes, skin, and clothing. Avoid ingestion and inhalation. On accidental exposure at the workplace, workers should immediately fl ush the eyes and exposed part of the body with plenty of water. Workers should avoid using the contaminated clothing and shoes.

p-Acetotoluidide Preparation Products And Raw materials

Raw materials

Preparation Products

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p-Acetotoluidide Suppliers

Zibo Qichuan Run Chemical Co., Ltd.
Tel
18553314927
Fax
0533-6312088
Email
77402664@qq.com
Country
China
ProdList
18
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43499
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18227
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12356
Advantage
60
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005;021-58099637-8009
Fax
021-58099609
Email
bin.wu@shlschem.com;sales@shlschem.com
Country
China
ProdList
9827
Advantage
59
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View Lastest Price from p-Acetotoluidide manufacturers

Career Henan Chemical Co
Product
p-Acetotoluidide 103-89-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
800kg
Release date
2019-12-25

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