2,5-DIBROMOTHIAZOLE
- Product Name
- 2,5-DIBROMOTHIAZOLE
- CAS No.
- 4175-78-4
- Chemical Name
- 2,5-DIBROMOTHIAZOLE
- Synonyms
- DibromoThiazole;2,5-Dibromo-1,3-thiazole;TZ-2Br;NSC 222407;2,5-Dibormothiazole;2,5-DIBROMOTHIAZOLE;2,5-Dibromothiazole>Thiazole, 2,5-dibroMo-;2,5-Dibromothiazole,97%;2,5-DIBROMOTHIAZOLE 95%
- CBNumber
- CB4709413
- Molecular Formula
- C3HBr2NS
- Formula Weight
- 242.92
- MOL File
- 4175-78-4.mol
2,5-DIBROMOTHIAZOLE Property
- Melting point:
- 45-49 °C (lit.)
- Boiling point:
- 242.8±13.0 °C(Predicted)
- Density
- 2.324±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- pka
- -0.88±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to brown
- InChI
- InChI=1S/C3HBr2NS/c4-2-1-6-3(5)7-2/h1H
- InChIKey
- XIBIQFJKUZZLLX-UHFFFAOYSA-N
- SMILES
- S1C(Br)=CN=C1Br
- CAS DataBase Reference
- 4175-78-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 524182
- Product name
- 2,5-Dibromothiazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $55.72
- Updated
- 2025/07/31
- Product number
- D3960
- Product name
- 2,5-Dibromothiazole
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $93
- Updated
- 2025/07/31
- Product number
- D426055
- Product name
- 2,5-Dibromothiazole
- Packaging
- 2.5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- D426055
- Product name
- 2,5-Dibromothiazole
- Packaging
- 25g
- Price
- $1055
- Updated
- 2021/12/16
- Product number
- 069594
- Product name
- 2,5-Dibromothiazole
- Purity
- 99%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
2,5-DIBROMOTHIAZOLE Chemical Properties,Usage,Production
Chemical Properties
White to brown crystalline powder
Uses
Used as a building block in material science.1,2
Uses
2,5-Dibromothiazole is used in the preparation of arylthiazolylpiperidine derivatives and analogs for use as survival motor neuron (SMN) protein production modulators.
Synthesis
3034-22-8
4175-78-4
2-Amino-5-bromothiazole (5.5 g, 30.72 mmol) was used as starting material and dissolved in acetonitrile (50 mL). Copper (II) bromide (3.43 g, 15.36 mmol) and isoamyl nitrite (4.9 mL, 36.87 mmol) were added sequentially. The reaction mixture was heated at 60 °C for 4 h with stirring. After completion of the reaction, the volatile solvent was removed by rotary evaporator. The residue was diluted with distilled water (50 mL) and subsequently extracted with ethyl acetate (25 mL x 2). The organic phases were combined, washed with saturated saline (50 mL) and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (60-120 mesh, eluent 10% ethyl acetate in hexane solution) to afford the target compound 2,5-dibromothiazole (5.05 g, yield 68%) as a yellow liquid. m/z 243.6 [M+2] by LCMS.
References
[1] Patent: WO2015/88045, 2015, A1. Location in patent: Paragraph 0260
[2] Patent: US2017/8885, 2017, A1. Location in patent: Paragraph 0672-0673
[3] Bulletin de la Societe Chimique de France, 1962, p. 2075 - 2078
[4] Journal of Organic Chemistry, 2017, vol. 82, # 11, p. 5947 - 5951
2,5-DIBROMOTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
2,5-DIBROMOTHIAZOLE Suppliers
- Tel
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- info@pschemicals.com
- Country
- The Netherlands
- ProdList
- 2724
- Advantage
- 58
- Tel
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- Fax
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- brunschwig@brunschwig.nl
- Country
- The Netherlands
- ProdList
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View Lastest Price from 2,5-DIBROMOTHIAZOLE manufacturers
- Product
- 2,5-Dibromothiazole 4175-78-4
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- 2,5-DIBROMOTHIAZOLE 4175-78-4
- Price
- US $35.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-19
- Product
- 2,5-Dibromothiazole 4175-78-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-12