4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID

Product Name: 4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID
CAS No.: 39091-01-5
Chemical Name: 4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID
Synonyms: 2-(3-PYRIDYL)-4-METHYLTHIAZOLE-5-CARBOXYLIC ACID;AKOS B029403;ASISCHEM C71524;BUTTPARK 51\01-30;TIMTEC-BB SBB011441;ASINEX-REAG BAS 07676575;2-(3-PYRIDYL)-4-METHYLTHIAZOLE-5-CARBOX&;4-METHYL-2-PYRID-3-YLTHIAZOLE-5-CARBOXYLIC ACID;4-Methyl-2-(3-pyridyl)thiazole-5-carboxylic Acid;4-METHYL-2-PYRIDIN-3-YL-THIAZOLE-5-CARBOXYLIC ACID
CBNumber: CB4715988
Molecular Formula: C10H8N2O2S
Formula Weight: 220.25
MOL File: 39091-01-5.mol

More

Less

4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID Property

Melting point:: 244-248 °C (dec.)(lit.)
Boiling point:: 459.0±55.0 °C(Predicted)
Density: 1.381±0.06 g/cm3(Predicted)
solubility: DMF: 1.5 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 1.71±0.37(Predicted)
InChI: 1S/C10H8N2O2S/c1-6-8(10(13)14)15-9(12-6)7-3-2-4-11-5-7/h2-5H,1H3,(H,13,14)
InChIKey: CJLQNROYBZEUGH-UHFFFAOYSA-N
SMILES: Cc1nc(sc1C(O)=O)-c2cccnc2
CAS DataBase Reference: 39091-01-5(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2934100090
Storage Class: 13 - Non Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 646040
Product name: 2-(3-Pyridyl)-4-methylthiazole-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $57.4
Updated: 2022/05/15

Sigma-Aldrich

Product number: 646040
Product name: 2-(3-Pyridyl)-4-methylthiazole-5-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $201
Updated: 2022/05/15

Cayman Chemical

Product number: 13036
Product name: 2-(3-pyridyl)-4-methyl-Thiazole-5-Carboxylic Acid
Purity: ≥98%
Packaging: 100mg
Price: $16
Updated: 2024/03/01

Cayman Chemical

Product number: 13036
Product name: 2-(3-pyridyl)-4-methyl-Thiazole-5-Carboxylic Acid
Purity: ≥98%
Packaging: 1g
Price: $82
Updated: 2024/03/01

Cayman Chemical

Product number: 13036
Product name: 2-(3-pyridyl)-4-methyl-Thiazole-5-Carboxylic Acid
Purity: ≥98%
Packaging: 250mg
Price: $32
Updated: 2024/03/01

More

Less

4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Description

2-(3-pyridyl)-4-methyl-Thiazole-5-carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

2-(3-Pyridyl)-4-methyl-thiazole-5-carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.

Synthesis

1. Synthesis of ethyl 2-bromo-4-methylthiazole-5-carboxylate: Ethyl 2-amino-4-methylthiazole-5-carboxylate is diazotized and brominated (with CuBr?).
2. Synthesis of target product: The bromo compound from step 1 undergoes Suzuki coupling with pyridine-3-boronic acid pinacol ester in the presence of Pd catalysts (XPhos-Pd-G2, XPhos).

4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID Suppliers

China 95 Finland 1 France 1 Germany 4 India 1 Japan 1 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 8 United States 16 Global 130

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chembon Pharmaceutical Co., Ltd.

Tel: 028-84252981
Fax: +86-28-84252965
Email: sales@chembon.com.cn
Country: China
ProdList: 850
Advantage: 64

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Email: 2819742715@qq.com
Country: China
ProdList: 3997
Advantage: 55

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

39091-01-5, 4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACIDRelated Search:

Chitosan 4-METHYL-2-(4-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID 4-METHYL-2-(2-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL 3-THIAZOL-2-YL-PYRIDINE 2-methyl-1,3-thiazole-5-carboxylic acid 4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID 4-METHYL-5-THIAZOLYL METHANOL 4-Methylthiazole-5-carboxylic acid 2,4-Dimethylthiazole-5-carboxylic acid ETHYL 4-METHYL-2-PYRIDIN-3-YL-1,3-THIAZOLE-5-CARBOXYLATE

2-(3-PYRIDYL)-4-METHYLTHIAZOLE-5-CARBOX&

4-METHYL-2-PYRID-3-YLTHIAZOLE-5-CARBOXYLIC ACID

4-Methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylic acid 95%

5-Thiazolecarboxylic acid, 4-Methyl-2-(3-pyridinyl)-

4-Methyl-2-(3-pyridinyl)-5-thiazolecarboxylic acid

TIMTEC-BB SBB011441

ASISCHEM C71524

ASINEX-REAG BAS 07676575

BUTTPARK 51\01-30

4-METHYL-2-(PYRIDIN-3-YL)-1,3-THIAZOLE-5-CARBOXYLIC ACID

4-METHYL-2-PYRIDIN-3-YL-THIAZOLE-5-CARBOXYLIC ACID

4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID

AKOS B029403

2-(3-PYRIDYL)-4-METHYLTHIAZOLE-5-CARBOXYLIC ACID

4-Methyl-2-(pyridin-3-yl)thiazol-5-carboxylic acid

4-Methyl-2-(3-pyridyl)thiazole-5-carboxylic Acid

39091-01-5

Heterocyclic Building Blocks

Thiazoles

Building Blocks

CARBOXYLIC ACID

Thiazole

Carboxylic Acids

Thiazoles, Isothiazoles & Benzothiazoles

Building Blocks

Heterocyclic Building Blocks

Thiazoles

Carboxylic Acids

Thiazoles, Isothiazoles &Benzothiazoles