(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL

Product Name: (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL
CAS No.: 50382-32-6
Chemical Name: (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL
Synonyms: RARECHEM AL BD 1354;2,4-DIMETHYLTHIAZOLE-5-METHANOL;2,4-Dimethyl-5-thiazolemethanol;5-Thiazolemethanol, 2,4-dimethyl-;(2,4-dimethyl-5-thiazolyl)methanol;(2,4-Dimethylthiazol-5-yl)methanol;(DIMETHYL-1,3-THIAZOL-5-YL)METHANOL;(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL;2,4-Dimethyl-5-(hydroxymethyl)-1,3-thiazole
CBNumber: CB7476952
Molecular Formula: C6H9NOS
Formula Weight: 143.21
MOL File: 50382-32-6.mol

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(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL Property

Melting point:: 56 °C
Boiling point:: 111-119°C 1mm
Density: 1.208±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.66±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41
Safety Statements: 26-37/39-39
Hazard Note: Irritant
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D480468
Product name: (2,4-Dimethyl-1,3-thiazol-5-yl)methanol
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Ark Pharm

Product number: P000214295
Product name: (2,4-Dimethylthiazol-5-yl)methanol
Purity: 98%
Packaging: 250mg
Price: $33
Updated: 2021/12/16

ChemScene

Product number: CS-W005611
Product name: (2,4-Dimethylthiazol-5-yl)methanol
Purity: ≥98.0%
Packaging: 1g
Price: $66
Updated: 2021/12/16

Ark Pharm

Product number: P000214295
Product name: (2,4-Dimethylthiazol-5-yl)methanol
Purity: 98%
Packaging: 1g
Price: $66
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H01-1-Y3
Product name: 2,4-Dimethyl-5-(hydroxymethyl)-1,3-thiazole
Packaging: 250mg
Price: $84
Updated: 2021/12/16

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(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL Chemical Properties,Usage,Production

Synthesis

7210-77-7

50382-32-6

General procedure for the synthesis of (2,4-dimethyl-1,3-thiazol-5-yl)methanol from ethyl 2,4-dimethylthiazole-5-carboxylate: ethyl 2,4-dimethylthiazole-5-carboxylate (500 mg, 2.70 mmol) was dissolved in anhydrous tetrahydrofuran (10 mL), and lithium aluminium hydroxide (205 mg, 5.40 mmol) was slowly added at 0 °C. After the reaction lasted for 1 h, the reaction was quenched by careful addition of water (10 mL). Subsequently, the reaction mixture was extracted with ethyl acetate (15 mL x 3), the organic phases were combined and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the reaction was purified by preparative thin layer chromatography (TLC) plates (unfolding reagent ratio 1:1 petroleum ether/ethyl acetate, Rf = 0.4) to afford the target product (2,4-dimethyl-1,3-thiazol-5-yl)methanol (300 mg, yellow solid) in 77% yield.1H NMR (400 MHz, methanol-d4) δ: 4.68 (s, 2H) 2.64 (s, 3H), 2.33 (s, 3H).

References

[1] Patent: EP3299371, 2018, A1. Location in patent: Paragraph 0252; 0253; 0254
[2] Journal of Medicinal Chemistry, 1973, vol. 16, p. 978 - 984
[3] Patent: EP1186604, 2002, A1. Location in patent: Page 131-132

(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL Suppliers

Belgium 1 China 68 Germany 3 India 1 United Kingdom 5 United States 17 Global 95

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View Lastest Price from (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL manufacturers

Career Henan Chemical Co

Product: (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL 50382-32-6
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

50382-32-6, (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOLRelated Search:

4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE 4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]THIAZOLE-5-CARBOXYLIC ACID 2,4-Dimethylthiazole-5-carboxylic acid ETHYL 2,4-DIMETHYLTHIAZOLE-5-CARBOXYLATE Ethyl 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate 2,4-Dimethylthiazole ETHYL 4-(TRIFLUOROMETHYL)-2-METHYLTHIAZOLE-5-CARBOXYLATE ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid 4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-PHENYL-1,3-THIAZOLE-4,5-DICARBOXYLIC ACID DIETHYL ESTER 4-METHYL-2-(2-PYRAZINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID ETHYL 4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLATE 2-OXO-2-PHENYLETHYL 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE

RARECHEM AL BD 1354

2,4-DIMETHYLTHIAZOLE-5-METHANOL

(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL

(2,4-Dimethylthiazol-5-yl)methanol

2,4-Dimethyl-5-(hydroxymethyl)-1,3-thiazole

(2,4-dimethyl-5-thiazolyl)methanol

5-Thiazolemethanol, 2,4-dimethyl-

2,4-Dimethyl-5-thiazolemethanol

(DIMETHYL-1,3-THIAZOL-5-YL)METHANOL

50382-32-6