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(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL

Product Name
(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL
CAS No.
50382-32-6
Chemical Name
(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL
Synonyms
RARECHEM AL BD 1354;2,4-DIMETHYLTHIAZOLE-5-METHANOL;2,4-Dimethyl-5-thiazolemethanol;5-Thiazolemethanol, 2,4-dimethyl-;(2,4-dimethyl-5-thiazolyl)methanol;(2,4-Dimethylthiazol-5-yl)methanol;(DIMETHYL-1,3-THIAZOL-5-YL)METHANOL;(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL;2,4-Dimethyl-5-(hydroxymethyl)-1,3-thiazole
CBNumber
CB7476952
Molecular Formula
C6H9NOS
Formula Weight
143.21
MOL File
50382-32-6.mol
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(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL Property

Melting point:
56 °C
Boiling point:
111-119°C 1mm
Density 
1.208±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
13.66±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-41
Safety Statements 
26-37/39-39
Hazard Note 
Irritant
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D480468
Product name
(2,4-Dimethyl-1,3-thiazol-5-yl)methanol
Packaging
500mg
Price
$175
Updated
2021/12/16
Matrix Scientific
Product number
084224
Product name
(2,4-Dimethyl-1,3-thiazol-5-yl)methanol
Purity
97%
Packaging
1g
Price
$194
Updated
2021/12/16
Ark Pharm
Product number
P000214295
Product name
(2,4-Dimethylthiazol-5-yl)methanol
Purity
98%
Packaging
5g
Price
$263
Updated
2021/12/16
ChemScene
Product number
CS-W005611
Product name
(2,4-Dimethylthiazol-5-yl)methanol
Purity
≥98.0%
Packaging
5g
Price
$264
Updated
2021/12/16
Ark Pharm
Product number
P000214295
Product name
(2,4-Dimethylthiazol-5-yl)methanol
Purity
98%
Packaging
250mg
Price
$33
Updated
2021/12/16
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(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL Chemical Properties,Usage,Production

Synthesis

7210-77-7

50382-32-6

General procedure for the synthesis of (2,4-dimethyl-1,3-thiazol-5-yl)methanol from ethyl 2,4-dimethylthiazole-5-carboxylate: ethyl 2,4-dimethylthiazole-5-carboxylate (500 mg, 2.70 mmol) was dissolved in anhydrous tetrahydrofuran (10 mL), and lithium aluminium hydroxide (205 mg, 5.40 mmol) was slowly added at 0 °C. After the reaction lasted for 1 h, the reaction was quenched by careful addition of water (10 mL). Subsequently, the reaction mixture was extracted with ethyl acetate (15 mL x 3), the organic phases were combined and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the reaction was purified by preparative thin layer chromatography (TLC) plates (unfolding reagent ratio 1:1 petroleum ether/ethyl acetate, Rf = 0.4) to afford the target product (2,4-dimethyl-1,3-thiazol-5-yl)methanol (300 mg, yellow solid) in 77% yield.1H NMR (400 MHz, methanol-d4) δ: 4.68 (s, 2H) 2.64 (s, 3H), 2.33 (s, 3H).

References

[1] Patent: EP3299371, 2018, A1. Location in patent: Paragraph 0252; 0253; 0254
[2] Journal of Medicinal Chemistry, 1973, vol. 16, p. 978 - 984
[3] Patent: EP1186604, 2002, A1. Location in patent: Page 131-132

(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL Suppliers

Belgium 1 China 68 Germany 3 India 1 United Kingdom 5 United States 17 Global 95
Maybridge Chemical Co., Ltd.
Tel
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Fax
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Country
Belgium
ProdList
6293
Advantage
73
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View Lastest Price from (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL manufacturers

Career Henan Chemical Co
Product
(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL 50382-32-6
Price
US $8.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10tons
Release date
2018-12-25

50382-32-6, (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOLRelated Search:

4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE 4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]THIAZOLE-5-CARBOXYLIC ACID 2,4-Dimethylthiazole-5-carboxylic acid ETHYL 2,4-DIMETHYLTHIAZOLE-5-CARBOXYLATE Ethyl 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate 2,4-Dimethylthiazole ETHYL 4-(TRIFLUOROMETHYL)-2-METHYLTHIAZOLE-5-CARBOXYLATE ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid 4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-PHENYL-1,3-THIAZOLE-4,5-DICARBOXYLIC ACID DIETHYL ESTER 4-METHYL-2-(2-PYRAZINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID ETHYL 4-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXYLATE 2-OXO-2-PHENYLETHYL 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE

  • RARECHEM AL BD 1354
  • 2,4-DIMETHYLTHIAZOLE-5-METHANOL
  • (2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHANOL
  • (2,4-Dimethylthiazol-5-yl)methanol
  • 2,4-Dimethyl-5-(hydroxymethyl)-1,3-thiazole
  • (2,4-dimethyl-5-thiazolyl)methanol
  • 5-Thiazolemethanol, 2,4-dimethyl-
  • 2,4-Dimethyl-5-thiazolemethanol
  • (DIMETHYL-1,3-THIAZOL-5-YL)METHANOL
  • 50382-32-6