ChemicalBook > CAS DataBase List > METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE

METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE

Product Name: METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE
CAS No.: 188187-03-3
Chemical Name: METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE
Synonyms: METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE;2-(BroMoMethyl)-3-chloro-benzoic acid Methyl ester;Benzoic acid, 2-(bromomethyl)-3-chloro-, methyl ester
CBNumber: CB4718686
Molecular Formula: C9H8BrClO2
Formula Weight: 263.52
MOL File: 188187-03-3.mol

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METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE Property

Boiling point:: 331.0±32.0 °C(Predicted)
Density: 1.561±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C9H8BrClO2/c1-13-9(12)6-3-2-4-8(11)7(6)5-10/h2-4H,5H2,1H3
InChIKey: BZXFVKQUKUJTIM-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=CC(Cl)=C1CBr

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Safety

RIDADR: 3261
HazardClass: 8
PackingGroup: Ⅱ

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 075675
Product name: Methyl 2-bromomethyl-3-chlorobenzoate
Purity: 95+%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

Matrix Scientific

Product number: 075675
Product name: Methyl 2-bromomethyl-3-chlorobenzoate
Purity: 95+%
Packaging: 1g
Price: $500
Updated: 2021/12/16

AK Scientific

Product number: W4060
Product name: 2-(Bromomethyl)-3-chloro-benzoicacidmethylester
Packaging: 5g
Price: $519
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0029368
Product name: BENZOIC ACID, 2-(BROMOMETHYL)-3-CHLORO-, METHYL ESTER
Purity: 95.00%
Packaging: 250MG
Price: $831.6
Updated: 2021/12/16

AK Scientific

Product number: W4060
Product name: 2-(Bromomethyl)-3-chloro-benzoicacidmethylester
Packaging: 10g
Price: $924
Updated: 2021/12/16

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METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE Chemical Properties,Usage,Production

Synthesis

99586-84-2

188187-03-3

Methyl 3-chloro-2-methylbenzoate (1 g, 5.42 mmol) was used as a raw material, which was mixed with carbon tetrachloride (13.3 ml), N-bromosuccinimide (1.06 g, 5.96 mmol) and benzoyl peroxide (3.5 mg, 0.0108 mmol) to form a suspension. The reaction mixture was heated in an oil bath at 90°C under nitrogen protection. After the reaction was carried out for 3 hours and 45 minutes, the heating was stopped. The reaction solution was sequentially diluted with water, ethyl acetate and saturated aqueous sodium bicarbonate. The organic layer was separated, washed with saturated aqueous sodium bicarbonate solution, dried over anhydrous magnesium sulfate, filtered and concentrated to afford the target product methyl 2-bromomethyl-3-chloro-benzoate (1.43 g, yield: 100%). The product was characterized by 1H-NMR (400 MHz, CDCl3) with chemical shifts δppm of 4.00 (3H, s), 5.12 (2H, s), 7.32 (1H, t, J = 8 Hz), 7.58 (1H, dd, J = 2,8 Hz), 7.86 (1H, dd, J = 2,8 Hz), respectively.

References

[1] Patent: US2013/65925, 2013, A1. Location in patent: Paragraph 0338; 0339
[2] Patent: EP2757103, 2014, A1. Location in patent: Paragraph 0215
[3] Patent: US5958968, 1999, A
[4] Patent: WO2004/58717, 2004, A1. Location in patent: Page 77
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 360 - 365

METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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188187-03-3, METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATERelated Search:

METHYL 2-BROMOMETHYL-6-CHLORO-BENZOATE Methyl 2-bromomethyl-3-nitrobenzoate METHYL 2-CYANO-5-METHOXYBENZOATE Methyl 2-bromomethyl-5-nitrobenzoate METHYL 2-BROMOMETHYL-5-FLUORO-BENZOATE 2-(BROMOMETHYL)BENZYL ALCOHOL, 95% 2-Chlorobenzyl bromide METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE Methyl 2-bromomethylbenzoate 2-(Bromomethyl)benzoic acid

METHYL 2-BROMOMETHYL-3-CHLORO-BENZOATE

Benzoic acid, 2-(bromomethyl)-3-chloro-, methyl ester

2-(BroMoMethyl)-3-chloro-benzoic acid Methyl ester

188187-03-3