Description References
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3,4-Dimethylphenol

Description References
Product Name
3,4-Dimethylphenol
CAS No.
95-65-8
Chemical Name
3,4-Dimethylphenol
Synonyms
3,4-XYLENOL;O-XYLENOL;1,3,4-Xylenol;Phenol,3,4-dimethyl-;3,4-DMP;NSC 1549;ai3-01552;FEMA 3596;o-4-Xylenol;as-o-xylenol
CBNumber
CB4723194
Molecular Formula
C8H10O
Formula Weight
122.16
MOL File
95-65-8.mol
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3,4-Dimethylphenol Property

Melting point:
65-68 °C
Boiling point:
227 °C(lit.)
Density 
1,138 g/cm3
vapor pressure 
0.475-130Pa at 25-66.2℃
FEMA 
3596 | 3,4-XYLENOL
refractive index 
1.5442
Flash point:
61 °C
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
pK1:10.32 (25°C)
form 
Crystalline Powder
color 
Off-white to pale cream
Odor
DIMETHYLPHENOL slightly smoky and earthy character provides nice roasted notes to seafood, mushroom and coffee flavors.flat dry
Odor Type
dry
explosive limit
1.4%(V)
Water Solubility 
SLIGHTLY SOLUBLE
Merck 
14,10082
JECFA Number
708
BRN 
1099267
Exposure limits
ACGIH: TWA 1 ppm
InChIKey
YCOXTKKNXUZSKD-UHFFFAOYSA-N
LogP
2.23 at 25℃
CAS DataBase Reference
95-65-8(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 3,4-dimethyl-(95-65-8)
EPA Substance Registry System
3,4-Dimethylphenol (95-65-8)
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Safety

Hazard Codes 
T,N
Risk Statements 
24/25-34-51/53
Safety Statements 
26-36/37/39-45-61
RIDADR 
UN 2261 6.1/PG 2
WGK Germany 
3
RTECS 
ZE6300000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29071400
Hazardous Substances Data
95-65-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D175404
Product name
3,4-Dimethylphenol
Purity
98%
Packaging
5g
Price
$26
Updated
2024/03/01
Sigma-Aldrich
Product number
D175404
Product name
3,4-Dimethylphenol
Purity
98%
Packaging
100g
Price
$67.1
Updated
2024/03/01
TCI Chemical
Product number
D0777
Product name
3,4-Dimethylphenol
Purity
>98.0%(GC)
Packaging
25g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
D0777
Product name
3,4-Dimethylphenol
Purity
>98.0%(GC)
Packaging
500g
Price
$180
Updated
2024/03/01
Alfa Aesar
Product number
A10599
Product name
3,4-Dimethylphenol
Purity
98+%
Packaging
100g
Price
$0
Updated
2021/12/16
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3,4-Dimethylphenol Chemical Properties,Usage,Production

Description

3,4-methylphenol (also 3,4-xylenol) has a flat, dry odor. It can be used as a flavoring agent without safety concern at current levels of intake. 3,4-dimethylphenol is used as an agent in the spectrophotometric method to determine nitrate in plants, soils, and water. It is also used to produce adhesive/sealant and resins as negative photoresist for electroplating.

References

[1] R. R. Elton-Bott, A modified spectrophotometric method for nitrate in plants, soils and water by nitration of 3,4-dimethylphenol, Analytica Chimica Acta, 1977, vol. 90, 215-221
[2] George A. Burdock, Fenaroli’s Handbook of Flavor Ingredients, Sixth Edition, 2010
[3] Chia L. Wang, John Davis, Bryan Lienke, Polyurethane systems having non-sag paintability and primerless adhesion on concrete, Patent, 2012
[4] Yasuo Masuda, Yasushi Washio, Koji Saito, Method of forming plated product using negative photoresist composition and photosensitive composition used therein, Patent, 2012

Chemical Properties

YELLOW TO BROWNISH CRYSTALLINE MASS

Occurrence

Reported found in coffee, tomato, parmesan and romano cheese, smoked fatty fish, white wine, katsuobushi (dried bonito) and wood vinegar.

Uses

Applications of 3,4-dimethylphenol:

  • It can react with ethyl cinnamates in trifluoroacetic acid to form the corresponding dihydrocoumarin derivatives.
  • Bromination of 3,4-dimethylphenol using bromine can lead to 6-bromo-3,4-dimethylphenol.
  • It can react with 1-fluoro-4-chloromethyl-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoro-borate) (Selectfluor? F-TEDA-BF4) to form 4-fluoro-3,4-dimethylcyclohexa-2,5-dienone.

Definition

ChEBI: 3,4-xylenol is a member of the class of phenols that is phenol substituted by methyl groups at positions 3 and 4. It derives from a hydride of an o-xylene.

Aroma threshold values

Detection: 1.2 ppm

General Description

Colorless to light tan crystalline powder or solid. Odor threshold 1.2 mg/L. Taste threshold 0.05 mg/L.

Air & Water Reactions

Hygroscopic. Insoluble in water.

Reactivity Profile

3,4-Dimethylphenol is incompatible with bases, acid chlorides, acid anhydrides, and oxidizing agents. 3,4-Dimethylphenol corrodes steel, brass, copper, and copper alloys.

Fire Hazard

Flash point data for 3,4-Dimethylphenol are not available. 3,4-Dimethylphenol is probably combustible.

Purification Methods

Heat 3,4-xylenol with an equal weight of conc H2SO4 at 103-105o for 2-3hours, then dilute it with four volumes of water, reflux it for 1hour, and either steam distil or extract it repeatedly with diethyl ether after cooling to room temperature. The steam distillate is also extracted and evaporated to dryness. (The purification process depends on the much slower sulfonation of 3,4-dimethylphenol than most of its likely contaminants.). It can also be crystallised from water, hexane or pet ether, and sublimed in a vacuum. [Kester Ind Eng Chem (Anal Ed) 24 770 1932, Bernasconi & Paschalis J Am Chem Soc 108 29691986, Beilstein 6 IV 3099.]

3,4-Dimethylphenol Preparation Products And Raw materials

Raw materials

3,5-Dimethylphenol o-Xylene Phenol crude 2,6-Dimethylphenol COAL TAR Polishing oil Xylenol

Preparation Products

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3,4-Dimethylphenol Suppliers

Americas 1 Belgium 3 Canada 2 China 181 Europe 4 France 1 Germany 10 India 10 Italy 1 Japan 3 Norway 1 Russia 1 Slovakia 1 Sweden 1 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 46 Global 286
Powerful Chemical (Shanghai) Co., Ltd.
Tel
021-62211590 18917958225
Fax
021-54339019
Email
pwfchem@163.com
Country
China
ProdList
72
Advantage
58
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
Nanjing Datang Chemical Co., Ltd
Tel
25-25-85431992 13951889906
Fax
+86-25-85287178
Email
vip@chemdatang.com
Country
China
ProdList
78
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
jiliang chemicals
Tel
21-62165282 15801962796;
Fax
021 61153784
Email
bidingchem@163.com
Country
China
ProdList
1165
Advantage
60
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View Lastest Price from 3,4-Dimethylphenol manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
3,4-Dimethylphenol 95-65-8
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-29
Hebei Mojin Biotechnology Co., Ltd
Product
3,4-Dimethylphenol 95-65-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-24
NANJING PASTEUR ChEMICAL CO.,LTD
Product
3,4-Dimethylphenol 95-65-8
Price
US $0.00-0.00/kg
Min. Order
1000kg
Purity
99.9%
Supply Ability
5000 tons
Release date
2023-11-01

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