ChemicalBook > CAS DataBase List > 3-METHYLGLUTACONIC ACID
3-METHYLGLUTACONIC ACID
- Product Name
- 3-METHYLGLUTACONIC ACID
- CAS No.
- 5746-90-7
- Chemical Name
- 3-METHYLGLUTACONIC ACID
- Synonyms
- NSC 249232;3-METHYLGLUTACONIC ACID;glutacouic acide 3-methyl;(E)-3-methylglutaconic acid;3-METHYL-2-PENTENEDIOIC ACID;3-METHYL-PENT-2-ENEDIOIC ACID;2-Pentenedioic acid, 3-methyl-;5746-90-7 3-METHYLGLUTACONIC ACID;3-Methyl-delta^2-penten-1,5-dioic acid;3-Methylglutaconic acid, mixture of E and Z isomers
- CBNumber
- CB4726610
- Molecular Formula
- C6H8O4
- Formula Weight
- 144.13
- MOL File
- 5746-90-7.mol
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3-METHYLGLUTACONIC ACID Property
- Melting point:
- 115 °C
- Boiling point:
- 399.4±25.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.36±0.10(Predicted)
- color
- White to Light Beige
- BRN
- 1722907
- Stability:
- Hygroscopic
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 06689
- Product name
- 3-Methylglutaconic acid, mixture of E and Z isomers
- Purity
- ≥98.0% (HPLC)
- Packaging
- 250mg
- Price
- $660
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 06689
- Product name
- 3-Methylglutaconic acid, mixture of E and Z isomers
- Purity
- ≥98.0% (HPLC)
- Packaging
- 50mg
- Price
- $136
- Updated
- 2022/05/15
TCI Chemical
- Product number
- M3764
- Product name
- 3-Methylglutaconic Acid
- Purity
- min. 95.0 %(total of isomers)
- Packaging
- 200MG
- Price
- $115
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M3764
- Product name
- 3-Methylglutaconic Acid
- Purity
- min. 95.0 %(total of isomers)
- Packaging
- 1G
- Price
- $345
- Updated
- 2025/07/31
TRC
- Product number
- M311565
- Product name
- 3-MethylglutaconicAcid
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
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3-METHYLGLUTACONIC ACID Chemical Properties,Usage,Production
Uses
3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)
Definition
ChEBI: A dicarboxylic acid comprising (E)-glutaconic acid carrying a 3-methyl substituent.
Biological Activity
3-Methylglutaconic acid is a metabolite (as the CoA thioester) in the leucine degradative pathway as well as the mevalonate shunt, a pathway th at links isoprenoid metabolism with mitochondrial acetyl-CoA metabolism. 3-Methylglutaconic acid accumulates in patients with a deficiency of 3-methylglutaconyl-CoA hydratase.
in vivo
| Animal Model: | Male Sprague-Dawley rats and male Hartley guinea-pigs[2] |
| Dosage: | 0.16 mL/kg, 90 min |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Increased initial blood pressure and heart rate in rats followed by vagal bradycardia and hypotension (rat) Developed three patterns of cardiovascular changes (Type 1: a period of sympathetically-mediated hypertension and tachycardia followed by vagal bradycardia; Type 2: Increased arterial pressure and heart rate, but no vagal activation; Type 3: exhibited no significant cardiovascular changes(Guinea-pigs). |
| Animal Model: | Male Wistar rats[3] |
| Dosage: | 45mg/kg for single dose, 4days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Decreased in NR2B expression on the whole cerebellum tissue and Purkinje cells. |
3-METHYLGLUTACONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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3-METHYLGLUTACONIC ACID Suppliers
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View Lastest Price from 3-METHYLGLUTACONIC ACID manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 3-METHYLGLUTACONIC ACID 5746-90-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-28
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
- Product
- 3-METHYLGLUTACONIC ACID 5746-90-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2021-12-22
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