ChemicalBook > CAS DataBase List > 3-METHYLGLUTACONIC ACID

3-METHYLGLUTACONIC ACID

Product Name: 3-METHYLGLUTACONIC ACID
CAS No.: 5746-90-7
Chemical Name: 3-METHYLGLUTACONIC ACID
Synonyms: NSC 249232;3-METHYLGLUTACONIC ACID;glutacouic acide 3-methyl;(E)-3-methylglutaconic acid;3-METHYL-2-PENTENEDIOIC ACID;3-METHYL-PENT-2-ENEDIOIC ACID;2-Pentenedioic acid, 3-methyl-;5746-90-7 3-METHYLGLUTACONIC ACID;3-Methyl-delta^2-penten-1,5-dioic acid;3-Methylglutaconic acid, mixture of E and Z isomers
CBNumber: CB4726610
Molecular Formula: C6H8O4
Formula Weight: 144.13
MOL File: 5746-90-7.mol

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3-METHYLGLUTACONIC ACID Property

Melting point:: 115 °C
Boiling point:: 399.4±25.0 °C(Predicted)
Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.36±0.10(Predicted)
color: White to Light Beige
BRN: 1722907
Stability:: Hygroscopic

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 06689
Product name: 3-Methylglutaconic acid, mixture of E and Z isomers
Purity: ≥98.0% (HPLC)
Packaging: 250mg
Price: $660
Updated: 2025/07/31

Sigma-Aldrich

Product number: 06689
Product name: 3-Methylglutaconic acid, mixture of E and Z isomers
Purity: ≥98.0% (HPLC)
Packaging: 50mg
Price: $136
Updated: 2022/05/15

TCI Chemical

Product number: M3764
Product name: 3-Methylglutaconic Acid
Purity: min. 95.0 %(total of isomers)
Packaging: 200MG
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: M3764
Product name: 3-Methylglutaconic Acid
Purity: min. 95.0 %(total of isomers)
Packaging: 1G
Price: $345
Updated: 2025/07/31

TRC

Product number: M311565
Product name: 3-MethylglutaconicAcid
Packaging: 250mg
Price: $125
Updated: 2021/12/16

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3-METHYLGLUTACONIC ACID Chemical Properties,Usage,Production

Uses

3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)

Definition

ChEBI: A dicarboxylic acid comprising (E)-glutaconic acid carrying a 3-methyl substituent.

Biological Activity

3-Methylglutaconic acid is a metabolite (as the CoA thioester) in the leucine degradative pathway as well as the mevalonate shunt, a pathway th at links isoprenoid metabolism with mitochondrial acetyl-CoA metabolism. 3-Methylglutaconic acid accumulates in patients with a deficiency of 3-methylglutaconyl-CoA hydratase.

in vivo

Animal Model:	Male Sprague-Dawley rats and male Hartley guinea-pigs^[2]
Dosage:	0.16 mL/kg, 90 min
Administration:	Intraperitoneal injection (i.p.)
Result:	Increased initial blood pressure and heart rate in rats followed by vagal bradycardia and hypotension (rat) Developed three patterns of cardiovascular changes (Type 1: a period of sympathetically-mediated hypertension and tachycardia followed by vagal bradycardia; Type 2: Increased arterial pressure and heart rate, but no vagal activation; Type 3: exhibited no significant cardiovascular changes(Guinea-pigs).

Animal Model:	Male Wistar rats^[3]
Dosage:	45mg/kg for single dose, 4days
Administration:	Intraperitoneal injection (i.p.)
Result:	Decreased in NR2B expression on the whole cerebellum tissue and Purkinje cells.

3-METHYLGLUTACONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-METHYLGLUTACONIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-METHYLGLUTACONIC ACID 5746-90-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-28

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: 3-METHYLGLUTACONIC ACID 5746-90-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20tons
Release date: 2021-12-22

5746-90-7, 3-METHYLGLUTACONIC ACIDRelated Search:

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3-Methylglutaconic acid, mixture of E and Z isomers

NSC 249232

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5746-90-7 3-METHYLGLUTACONIC ACID

3-Methylglutaconic acid, mixture of <i>E</i> and <i>Z</i> isomers

5746-90-7

5740-90-7