AG 1478 HYDROCHLORIDE

Product Name: AG 1478 HYDROCHLORIDE
CAS No.: 153436-53-4
Chemical Name: AG 1478 HYDROCHLORIDE
Synonyms: -1478);AG-1478;AG1478HCl;NSC 693255;AG-1478, >98%;AG-1478 AG1478;AG-1478 (NSC-693255);-1478 (Tyrphostin Ag;AG 1478 HYDROCHLORIDE;AG-1478 (Tyrphostin AG-1478)
CBNumber: CB4728982
Molecular Formula: C16H14ClN3O2
Formula Weight: 315.75
MOL File: 153436-53-4.mol

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AG 1478 HYDROCHLORIDE Property

Melting point:: 247 °C(dec.)
Boiling point:: 458.5±45.0 °C(Predicted)
Density: 1.337
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: insoluble in H2O; ≥15.8 mg/mL in DMSO; ≥2.38 mg/mL in EtOH with gentle warming
pka: 5.54±0.30(Predicted)
form: White to light yellow solid.
color: Light orange to Yellow to Green
λmax: 332nm(lit.)

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Safety

RTECS: VA0953000
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2944
Product name: Tyrphostin AG 1478
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $464
Updated: 2024/03/01

Cayman Chemical

Product number: 10010244
Product name: AG 1478
Purity: ≥98%
Packaging: 1mg
Price: $22
Updated: 2024/03/01

Cayman Chemical

Product number: 10010244
Product name: AG 1478
Purity: ≥98%
Packaging: 5mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 10010244
Product name: AG 1478
Purity: ≥98%
Packaging: 10mg
Price: $167
Updated: 2024/03/01

Cayman Chemical

Product number: 10010244
Product name: AG 1478
Purity: ≥98%
Packaging: 25mg
Price: $363
Updated: 2024/03/01

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AG 1478 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.

Uses

AG 1478 Hydrochloride is an epidermal growth factor receptor tyrosine kinase inhibior (EGFR inhibtor).

Definition

ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.

Biological Activity

Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M).

target

EGFR

AG 1478 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 1478 HYDROCHLORIDE Suppliers

China 107 Germany 1 India 2 Japan 3 United Kingdom 7 United States 25 Global 145

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View Lastest Price from AG 1478 HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: AG 1478 HYDROCHLORIDE 153436-53-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

153436-53-4, AG 1478 HYDROCHLORIDERelated Search:

Neratinib Poziotinib (HM781-36B) CO-1686 Dacomitinib (PF299804) AZD-9291 Nintedanib MK-2206 2HCl WORTMANNIN PD 98059 LY 294002 HYDROCHLORIDE Olaparib AG 1478 Gefitinib Gefitinib O-Methyl-D3 AG 1478 HYDROCHLORIDE N-(3-CHLORO-2-METHYLPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE (3-CHLORO-4-FLUORO-PHENYL)-(6,7-DIMETHOXY-QUINAZOLIN-4-YL)-AMINE N-(3,4-DICHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE

N-(3-CHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINANINE HYDROCHLORIDE

4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HCL

4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE

AG-1478

AG 1478 HYDROCHLORIDE

Tyrphostin AG 1478, free base >99%

NSC 693255

(3-Chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine

AG1478HCl

AG-1478 (Tyrphostin AG-1478)

AG-1478 (NSC-693255)

AG-1478, 97.5%, a selective EGFR inhibitor

AG1478; TYRPHOSTIN AG1478; AG 1478; NSC 693255

AG1478; TYRPHOSTIN AG1478; AG 1478

AG-1478, >98%

-1478 (Tyrphostin Ag

-1478)

AG 1478 HYDROCHLORIDE USP/EP/BP

AG-1478 AG1478

AG-1478 hydrochloride/Tyrphostin AG 1478

153436-53-4

C16H14ClN3O2HCl

Inhibitors

API

Inhibitor